benzoic acid 1-[2-(tert-butyldiphenylsilanyloxy)ethyl]-4-chloro-1-(trimethylsilanyl)but-2-ynyl ester

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Chemical Name:benzoic acid 1-[2-(tert-butyldiphenylsilanyloxy)ethyl]-4-chloro-1-(trimethylsilanyl)but-2-ynyl ester
CAS No.:438581-38-5
Molecular Formula:C₃₂H₃₉ClO₃Si₂
Molecular Weight:563.284
Hs Code.:

Synonyms:benzoic acid 1-[2-(tert-butyldiphenylsilanyloxy)ethyl]-4-chloro-1-(trimethylsilanyl)but-2-ynyl ester

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Chemical Property of benzoic acid 1-[2-(tert-butyldiphenylsilanyloxy)ethyl]-4-chloro-1-(trimethylsilanyl)but-2-ynyl ester

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Technology Process of benzoic acid 1-[2-(tert-butyldiphenylsilanyloxy)ethyl]-4-chloro-1-(trimethylsilanyl)but-2-ynyl ester

There total 4 articles about benzoic acid 1-[2-(tert-butyldiphenylsilanyloxy)ethyl]-4-chloro-1-(trimethylsilanyl)but-2-ynyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 93-97-0
benzoic acid anhydride

: 438581-37-4
1-(tert-butyldiphenylsilanyloxy)-6-chloro-3-(trimethylsilanyl)hex-4-yn-3-ol

: 438581-38-5
benzoic acid 1-[2-(tert-butyldiphenylsilanyloxy)ethyl]-4-chloro-1-(trimethylsilanyl)but-2-ynyl ester

Guidance literature:: With triethylamine; magnesium bromide; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1021/ol025861m

Reference yield:

: 126822-71-7
1-iodo-2-<(tert-butyldiphenylsilyl)oxy>ethane

: 438581-38-5
benzoic acid 1-[2-(tert-butyldiphenylsilanyloxy)ethyl]-4-chloro-1-(trimethylsilanyl)but-2-ynyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -20 °C

1.2: tetrahydrofuran; hexane / -78 - 20 °C

2.1: 0.493 g / iron(III) nitrate nonahydrate; basic alumina / hexane / 1 h / 43 °C

3.1: n-butyllithium / diethyl ether; hexane / 0.17 h / -78 °C

3.2: 71 percent / diethyl ether; hexane / 0.17 h / -78 °C

4.1: 80 percent / triethylamine; magnesium bromide / CH₂Cl₂ / 3 h / 20 °C

With aluminum oxide; n-butyllithium; ferric nitrate; triethylamine; magnesium bromide; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;
DOI:10.1021/ol025861m

Reference yield:

: 438581-36-3
3-(tert-butyldiphenylsilanyloxy)-1-(trimethylsilanyl)propan-1-one

: 438581-38-5
benzoic acid 1-[2-(tert-butyldiphenylsilanyloxy)ethyl]-4-chloro-1-(trimethylsilanyl)but-2-ynyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / diethyl ether; hexane / 0.17 h / -78 °C

1.2: 71 percent / diethyl ether; hexane / 0.17 h / -78 °C

2.1: 80 percent / triethylamine; magnesium bromide / CH₂Cl₂ / 3 h / 20 °C

With n-butyllithium; triethylamine; magnesium bromide; In diethyl ether; hexane; dichloromethane;
DOI:10.1021/ol025861m