7-Benzofurancarbonylchloride,2,3-dihydro-5-methyl-(6CI,9CI)

Base Information

• Chemical Name: 7-Benzofurancarbonylchloride,2,3-dihydro-5-methyl-(6CI,9CI)
• CAS No.: 103261-02-5
• Molecular Formula: C₁₀H₉ClO₂
• Molecular Weight: 196.633
• Mol file: 103261-02-5.mol

Synonyms:7-Benzofurancarbonylchloride,2,3-dihydro-5-methyl-(6CI,9CI)

Chemical Property of 7-Benzofurancarbonylchloride,2,3-dihydro-5-methyl-(6CI,9CI)

Chemical Property:

• PSA: 26.30000
• LogP: 2.30890

Purity/Quality:

7-BENZOFURANCARBONYLCHLORIDE,2,3-DIHYDRO-5-METHYL- 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-Benzofurancarbonylchloride,2,3-dihydro-5-methyl-(6CI,9CI)

There total 13 articles about 7-Benzofurancarbonylchloride,2,3-dihydro-5-methyl-(6CI,9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-Methylsalicylic acid (89-56-5) → 5-methyl-2,3-dihydro-benzofuran-7-carbonyl chloride (103261-02-5)

Guidance literature:

Multi-step reaction with 6 steps

1: HCl (gas) / Heating

2: K₂CO₃ / acetone / Heating

3: N-methylpyrrolidinone / 7 h / Heating

4: 90percent HCOOH / 3 h / Heating

5: NaOH / H₂O / 3 h / Heating

6: SOCl₂ / 3 h / Heating

With 1-methyl-pyrrolidin-2-one; hydrogenchloride; sodium hydroxide; formic acid; thionyl chloride; potassium carbonate; In water; acetone;

DOI:10.1021/jm00080a016

Reference yield:

methyl 6-hydroxy-m-toluate (22717-57-3) → 5-methyl-2,3-dihydro-benzofuran-7-carbonyl chloride (103261-02-5)

Guidance literature:

Multi-step reaction with 5 steps

1: K₂CO₃ / acetone / Heating

2: N-methylpyrrolidinone / 7 h / Heating

3: 90percent HCOOH / 3 h / Heating

4: NaOH / H₂O / 3 h / Heating

5: SOCl₂ / 3 h / Heating

With 1-methyl-pyrrolidin-2-one; sodium hydroxide; formic acid; thionyl chloride; potassium carbonate; In water; acetone;

DOI:10.1021/jm00080a016

Reference yield:

2-Hydroxy-5-methyl-3-vinyl-benzoic acid methyl ester → 5-methyl-2,3-dihydro-benzofuran-7-carbonyl chloride (103261-02-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 90percent HCOOH / 3 h / Heating

2: NaOH / H₂O / 3 h / Heating

3: SOCl₂ / 3 h / Heating

With sodium hydroxide; formic acid; thionyl chloride; In water;

DOI:10.1021/jm00080a016

upstream raw materials:

5-methyl-2,3-dihydro-benzofuran-7-carboxylic acid

5-Methylsalicylic acid

methyl 6-hydroxy-m-toluate

5-methyl-2,3-dihydrobenzofuran

Refernces