(S)-N-(2-naphthalen-2-yl-ethyl)-P,P-diphenylphosphinamide

Base Information

• Chemical Name: (S)-N-(2-naphthalen-2-yl-ethyl)-P,P-diphenylphosphinamide
• CAS No.: 106651-19-8
• Molecular Formula: C₂₄H₂₂NOP
• Molecular Weight: 371.419
• Mol file: 106651-19-8.mol

Synonyms:(S)-N-(2-naphthalen-2-yl-ethyl)-P,P-diphenylphosphinamide

Chemical Property of (S)-N-(2-naphthalen-2-yl-ethyl)-P,P-diphenylphosphinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N-(2-naphthalen-2-yl-ethyl)-P,P-diphenylphosphinamide

There total 10 articles about (S)-N-(2-naphthalen-2-yl-ethyl)-P,P-diphenylphosphinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

dimethyl zinc(II) (544-97-8) + N-(naphthalen-2-ylmethylene)-P,P-diphenylphosphinic amide (98837-39-9,119701-93-8) → (R)-N-(1-naphthalen-2-ylethyl)-p,p-diphenylphosphinc amide + (S)-N-(2-naphthalen-2-yl-ethyl)-P,P-diphenylphosphinamide (106651-19-8)

Guidance literature:

With chloro(1,5-cyclooctadiene)rhodium(I) dimer; [2R-[1(2'R*,5'R*),2a,5b]]-1,1'-(1,2-phenylene)bis[2,5-dimethylphospholane]; In tetrahydrofuran; toluene; at 20 ℃; for 5.6h; optical yield given as %ee; enantioselective reaction; Inert atmosphere; Reflux;

DOI:10.1016/j.tetasy.2009.09.020

Reference yield: 78.0%

N-[(E)-1-(2-naphthyl)ethylidene]diphenylphosphinic amide (942066-02-6) → (S)-N-(2-naphthalen-2-yl-ethyl)-P,P-diphenylphosphinamide (106651-19-8)

Guidance literature:

With C₃₅H₄₂ClFeNOP₂; potassium tert-butylate; hydrogen; In toluene; at 80 ℃; for 20h; enantioselective reaction; Glovebox; Inert atmosphere;

DOI:10.1021/acs.joc.9b01964

Reference yield: 72.0%

C24H20NOP (82572-08-5) → (S)-N-(2-naphthalen-2-yl-ethyl)-P,P-diphenylphosphinamide (106651-19-8)

Guidance literature:

C₂₄H₂₀NOP; With Triethoxysilane; zinc diacetate; (1R,2R)-N,N’-dibenzyl-1,2-diphenylethane-1,2-diamine; at 25 ℃; Inert atmosphere;

With sodium hydroxide; In methanol; enantioselective reaction; Inert atmosphere;

DOI:10.1002/cctc.201601140

upstream raw materials:

C₂₄H₂₀NOP

N-[(E)-1-(2-naphthyl)ethylidene]diphenylphosphinic amide

dimethyl zinc(II)

N-(naphthalen-2-ylmethylene)-P,P-diphenylphosphinic amide