(2S,3S,4R,5S,6R)-2-(3-(4-(3-(2H-tetrazol-5-yl)propyl)benzyl)-4-methylphenyl)-6-(methylthio)tetrahydro-2H-pyran-3,4,5-triyl triacetate

Base Information

Chemical Name:(2S,3S,4R,5S,6R)-2-(3-(4-(3-(2H-tetrazol-5-yl)propyl)benzyl)-4-methylphenyl)-6-(methylthio)tetrahydro-2H-pyran-3,4,5-triyl triacetate
CAS No.:1610955-20-8
Molecular Formula:C₃₀H₃₆N₄O₇S
Molecular Weight:596.704
Hs Code.:

Synonyms:(2S,3S,4R,5S,6R)-2-(3-(4-(3-(2H-tetrazol-5-yl)propyl)benzyl)-4-methylphenyl)-6-(methylthio)tetrahydro-2H-pyran-3,4,5-triyl triacetate

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Chemical Property of (2S,3S,4R,5S,6R)-2-(3-(4-(3-(2H-tetrazol-5-yl)propyl)benzyl)-4-methylphenyl)-6-(methylthio)tetrahydro-2H-pyran-3,4,5-triyl triacetate

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Technology Process of (2S,3S,4R,5S,6R)-2-(3-(4-(3-(2H-tetrazol-5-yl)propyl)benzyl)-4-methylphenyl)-6-(methylthio)tetrahydro-2H-pyran-3,4,5-triyl triacetate

There total 12 articles about (2S,3S,4R,5S,6R)-2-(3-(4-(3-(2H-tetrazol-5-yl)propyl)benzyl)-4-methylphenyl)-6-(methylthio)tetrahydro-2H-pyran-3,4,5-triyl triacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1610955-21-9
C₃₀H₃₅NO₇S

: 1610955-20-8
(2S,3S,4R,5S,6R)-2-(3-(4-(3-(2H-tetrazol-5-yl)propyl)benzyl)-4-methylphenyl)-6-(methylthio)tetrahydro-2H-pyran-3,4,5-triyl triacetate

Guidance literature:: With trimethylsilylazide; di(n-butyl)tin oxide; In toluene; at 90 ℃; for 18h;

Reference yield:

: 1500921-65-2
(5-bromo-2-methylphenyl)(4-chlorophenyl)methanone

: 1610955-20-8
(2S,3S,4R,5S,6R)-2-(3-(4-(3-(2H-tetrazol-5-yl)propyl)benzyl)-4-methylphenyl)-6-(methylthio)tetrahydro-2H-pyran-3,4,5-triyl triacetate

Guidance literature:: Multi-step reaction with 9 steps

1.1: triethylsilane; boron trifluoride diethyl etherate / acetonitrile / 2 h / 0 - 60 °C

2.1: tert-butylmagnesium chloride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

2.2: 1.5 h / -78 - 60 °C

3.1: sodium tetrahydroborate; cerium(III) chloride heptahydrate; methanol; water; sodium hydroxide / 0.25 h

4.1: water; acetic acid / 7 h / 100 °C

5.1: dmap; triethylamine / acetonitrile / 1 h / 20 °C

6.1: thiourea; trimethylsilyl trifluoromethanesulfonate / 1,4-dioxane / 3 h / 80 °C

6.2: 18 h / 20 °C

7.1: tri tert-butylphosphoniumtetrafluoroborate; N-Methyldicyclohexylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1-methyl-pyrrolidin-2-one / 0.33 h / 160 °C / Microwave irradiation

8.1: palladium 10% on activated carbon; hydrogen / methanol / 5 h / 2068.65 Torr

9.1: trimethylsilylazide; di(n-butyl)tin oxide / toluene / 18 h / 90 °C

With methanol; triethylsilane; dmap; sodium tetrahydroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; trimethylsilyl trifluoromethanesulfonate; cerium(III) chloride heptahydrate; trimethylsilylazide; N-Methyldicyclohexylamine; palladium 10% on activated carbon; boron trifluoride diethyl etherate; tert-butylmagnesium chloride; water; hydrogen; di(n-butyl)tin oxide; acetic acid; triethylamine; thiourea; sodium hydroxide; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; toluene; acetonitrile;

Reference yield:

: 1610954-86-3
(3-(4-chlorobenzyl)-4-methylphenyl)((3aS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methanone

: 1610955-20-8
(2S,3S,4R,5S,6R)-2-(3-(4-(3-(2H-tetrazol-5-yl)propyl)benzyl)-4-methylphenyl)-6-(methylthio)tetrahydro-2H-pyran-3,4,5-triyl triacetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium tetrahydroborate; cerium(III) chloride heptahydrate; methanol; water; sodium hydroxide / 0.25 h

2.1: water; acetic acid / 7 h / 100 °C

3.1: dmap; triethylamine / acetonitrile / 1 h / 20 °C

4.1: thiourea; trimethylsilyl trifluoromethanesulfonate / 1,4-dioxane / 3 h / 80 °C

4.2: 18 h / 20 °C

5.1: tri tert-butylphosphoniumtetrafluoroborate; N-Methyldicyclohexylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1-methyl-pyrrolidin-2-one / 0.33 h / 160 °C / Microwave irradiation

6.1: palladium 10% on activated carbon; hydrogen / methanol / 5 h / 2068.65 Torr

7.1: trimethylsilylazide; di(n-butyl)tin oxide / toluene / 18 h / 90 °C

With methanol; dmap; sodium tetrahydroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; trimethylsilyl trifluoromethanesulfonate; cerium(III) chloride heptahydrate; trimethylsilylazide; N-Methyldicyclohexylamine; palladium 10% on activated carbon; water; hydrogen; di(n-butyl)tin oxide; acetic acid; triethylamine; thiourea; sodium hydroxide; tri tert-butylphosphoniumtetrafluoroborate; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; toluene; acetonitrile;