(3-(4-chlorobenzyl)-4-methylphenyl)((3aS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methanone

Base Information

Chemical Name:(3-(4-chlorobenzyl)-4-methylphenyl)((3aS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methanone
CAS No.:1610954-86-3
Molecular Formula:C₂₂H₂₃ClO₅
Molecular Weight:402.875
Hs Code.:

Synonyms:(3-(4-chlorobenzyl)-4-methylphenyl)((3aS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methanone

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Chemical Property of (3-(4-chlorobenzyl)-4-methylphenyl)((3aS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methanone

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Technology Process of (3-(4-chlorobenzyl)-4-methylphenyl)((3aS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methanone

There total 5 articles about (3-(4-chlorobenzyl)-4-methylphenyl)((3aS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1103738-19-7
((3aS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(morpholin-4-yl)methanone

: 1610954-85-2
4-bromo-2-(4-chlorobenzyl)-1-methylbenzene

: 1610954-86-3
(3-(4-chlorobenzyl)-4-methylphenyl)((3aS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methanone

Guidance literature:: ((3aS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(morpholin-4-yl)methanone; With tert-butylmagnesium chloride; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

4-bromo-2-(4-chlorobenzyl)-1-methylbenzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 3h; Inert atmosphere;

Reference yield:

: 79669-49-1
5-bromo-2-methylbenzoic acid

: 1610954-86-3
(3-(4-chlorobenzyl)-4-methylphenyl)((3aS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl dichloride; dmap / dichloromethane / 20 °C

2.1: triethylamine / dichloromethane / 0 - 20 °C

3.1: tetrahydrofuran / 2 h / 20 °C

4.1: triethylsilane; boron trifluoride diethyl etherate / acetonitrile / 2 h / 0 - 60 °C

5.1: tert-butylmagnesium chloride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

5.2: 1.5 h / -78 - 60 °C

With triethylsilane; dmap; oxalyl dichloride; boron trifluoride diethyl etherate; tert-butylmagnesium chloride; triethylamine; In tetrahydrofuran; dichloromethane; acetonitrile;

Reference yield:

: 21900-41-4
5-bromo-2-methylbenzoyl?chloride

: 1610954-86-3
(3-(4-chlorobenzyl)-4-methylphenyl)((3aS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 0 - 20 °C

2.1: tetrahydrofuran / 2 h / 20 °C

3.1: triethylsilane; boron trifluoride diethyl etherate / acetonitrile / 2 h / 0 - 60 °C

4.1: tert-butylmagnesium chloride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

4.2: 1.5 h / -78 - 60 °C

With triethylsilane; boron trifluoride diethyl etherate; tert-butylmagnesium chloride; triethylamine; In tetrahydrofuran; dichloromethane; acetonitrile;