{3-[4-(2-fluoro-4-nitrophenoxy)-6-methoxyquinolin-7-yloxy]propyl}carbamic acid tert-butyl ester

Base Information

Chemical Name:{3-[4-(2-fluoro-4-nitrophenoxy)-6-methoxyquinolin-7-yloxy]propyl}carbamic acid tert-butyl ester
CAS No.:1361031-47-1
Molecular Formula:C₂₄H₂₆FN₃O₇
Molecular Weight:487.485
Hs Code.:

Synonyms:{3-[4-(2-fluoro-4-nitrophenoxy)-6-methoxyquinolin-7-yloxy]propyl}carbamic acid tert-butyl ester

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Chemical Property of {3-[4-(2-fluoro-4-nitrophenoxy)-6-methoxyquinolin-7-yloxy]propyl}carbamic acid tert-butyl ester

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Technology Process of {3-[4-(2-fluoro-4-nitrophenoxy)-6-methoxyquinolin-7-yloxy]propyl}carbamic acid tert-butyl ester

There total 4 articles about {3-[4-(2-fluoro-4-nitrophenoxy)-6-methoxyquinolin-7-yloxy]propyl}carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 479690-08-9
1-(2-fluoro-4-nitrophenyl)-6-hydroxy-7-methoxy-quinoline

: 83948-53-2
3-bromopropylamine tert-butylcarbamate

: 1361031-47-1
{3-[4-(2-fluoro-4-nitrophenoxy)-6-methoxyquinolin-7-yloxy]propyl}carbamic acid tert-butyl ester

Guidance literature:: With caesium carbonate; potassium iodide; In acetonitrile; at 20 ℃; for 3.75h; Reflux;
DOI:10.1021/acs.jmedchem.8b00672

Reference yield:

: 403-19-0
2-fluoro-4-nitrophenol

: 1361031-47-1
{3-[4-(2-fluoro-4-nitrophenoxy)-6-methoxyquinolin-7-yloxy]propyl}carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / chlorobenzene / 48 h / Reflux

2.1: hydrogen bromide; acetic acid / 2 h / 20 °C

2.2: 24 h

3.1: caesium carbonate; potassium iodide / acetonitrile / 3.75 h / 20 °C / Reflux

With hydrogen bromide; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; potassium iodide; In chlorobenzene; acetonitrile;
DOI:10.1021/acs.jmedchem.8b00672

Reference yield:

: 286371-49-1
7-(benzyloxy)-4-chloro-6-methoxyquinoline

: 1361031-47-1
{3-[4-(2-fluoro-4-nitrophenoxy)-6-methoxyquinolin-7-yloxy]propyl}carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / chlorobenzene / 48 h / Reflux

2.1: hydrogen bromide; acetic acid / 2 h / 20 °C

2.2: 24 h

3.1: caesium carbonate; potassium iodide / acetonitrile / 3.75 h / 20 °C / Reflux

With hydrogen bromide; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; potassium iodide; In chlorobenzene; acetonitrile;
DOI:10.1021/acs.jmedchem.8b00672