N-[2-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-ethyl]-4-methyl-benzenesulfonamide

Base Information

• Chemical Name: N-[2-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-ethyl]-4-methyl-benzenesulfonamide
• CAS No.: 215923-82-3
• Molecular Formula: C₂₃H₂₃ClN₂O₂S
• Molecular Weight: 426.967
• Mol file: 215923-82-3.mol

Synonyms:N-[2-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-ethyl]-4-methyl-benzenesulfonamide

Chemical Property of N-[2-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-ethyl]-4-methyl-benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-ethyl]-4-methyl-benzenesulfonamide

There total 1 articles about N-[2-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-ethyl]-4-methyl-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(p-toluenesulfonyl)aziridine (3634-89-7) + 8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine (38093-12-8) → N-[2-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-ethyl]-4-methyl-benzenesulfonamide (215923-82-3)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; Yield given; 1.) -78 deg C;

DOI:10.1016/S0040-4039(98)01714-6

Reference yield: 87.0%

tert-butyldimethylsilyl chloride (18162-48-6) + N-[2-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-ethyl]-4-methyl-benzenesulfonamide (215923-82-3) → C29H37ClN2O2SSi (215923-83-4)

Guidance literature:

With sodium hydride; In tetrahydrofuran; 1.) 0 deg C;

DOI:10.1016/S0040-4039(98)01714-6

Reference yield:

N-[2-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-ethyl]-4-methyl-benzenesulfonamide (215923-82-3) → C25H25ClN2 (215923-88-9)

Guidance literature:

Multi-step reaction with 7 steps

1: 87 percent / 1.) NaH / tetrahydrofuran / 1.) 0 deg C

2: 44 percent / 1.) n-BuLi / tetrahydrofuran / 1.) -78 deg C

3: Bu₄NF / tetrahydrofuran / 20 °C

4: 61 percent / toluene / 110 °C

5: 75 percent / conc. H₂SO₄ / 75 °C

6: 90 percent / 1.) NaH / dimethylformamide / 1.) 0 deg C

7: 46 percent / LAH / tetrahydrofuran / 75 °C

With lithium aluminium tetrahydride; n-butyllithium; sulfuric acid; tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;

DOI:10.1016/S0040-4039(98)01714-6

upstream raw materials:

N-(p-toluenesulfonyl)aziridine

8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine

Downstream raw materials:

C₂₉H₃₇ClN₂O₂SSi

C₂₅H₂₅ClN₂

C₂₅H₂₃ClN₂O

C₂₅H₂₃ClN₂O₃S