tert-butyl (5-(5-chloro-2-(4-(N-(2,4-dimethoxybenzyl)-N-(1,2,4-thiadiazol-5-yl)sulfamoyl)-2,5-difluorophenoxy)-phenyl)-benzo[d]isoxazol-3-yl)(methyl)carbamate

Base Information

Chemical Name:tert-butyl (5-(5-chloro-2-(4-(N-(2,4-dimethoxybenzyl)-N-(1,2,4-thiadiazol-5-yl)sulfamoyl)-2,5-difluorophenoxy)-phenyl)-benzo[d]isoxazol-3-yl)(methyl)carbamate
CAS No.:1432913-96-6
Molecular Formula:C₃₆H₃₂ClF₂N₅O₈S₂
Molecular Weight:800.261
Hs Code.:

tert-butyl (5-(5-chloro-2-(4-(N-(2,4-dimethoxybenzyl)-N-(1,2,4-thiadiazol-5-yl)sulfamoyl)-2,5-difluorophenoxy)-phenyl)-benzo[d]isoxazol-3-yl)(methyl)carbamate

Synonyms:tert-butyl (5-(5-chloro-2-(4-(N-(2,4-dimethoxybenzyl)-N-(1,2,4-thiadiazol-5-yl)sulfamoyl)-2,5-difluorophenoxy)-phenyl)-benzo[d]isoxazol-3-yl)(methyl)carbamate

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Chemical Property of tert-butyl (5-(5-chloro-2-(4-(N-(2,4-dimethoxybenzyl)-N-(1,2,4-thiadiazol-5-yl)sulfamoyl)-2,5-difluorophenoxy)-phenyl)-benzo[d]isoxazol-3-yl)(methyl)carbamate

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Technology Process of tert-butyl (5-(5-chloro-2-(4-(N-(2,4-dimethoxybenzyl)-N-(1,2,4-thiadiazol-5-yl)sulfamoyl)-2,5-difluorophenoxy)-phenyl)-benzo[d]isoxazol-3-yl)(methyl)carbamate

There total 10 articles about tert-butyl (5-(5-chloro-2-(4-(N-(2,4-dimethoxybenzyl)-N-(1,2,4-thiadiazol-5-yl)sulfamoyl)-2,5-difluorophenoxy)-phenyl)-benzo[d]isoxazol-3-yl)(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1432913-93-3
tert-butyl (5-(5-chloro-2-(4-(N-(2,4-dimethoxybenzyl)-N-(1,2,4-thiadiazol-5-yl)sulfamoyl)-2,5-difluorophenoxy)phenyl)benzo[d]isoxazol-3-yl)carbamate

: 74-88-4
methyl iodide

: 1432913-96-6
tert-butyl (5-(5-chloro-2-(4-(N-(2,4-dimethoxybenzyl)-N-(1,2,4-thiadiazol-5-yl)sulfamoyl)-2,5-difluorophenoxy)-phenyl)-benzo[d]isoxazol-3-yl)(methyl)carbamate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/acsmedchemlett.5b00447

Reference yield:

: 179897-89-3
5-Bromo-2-fluoro-benzonitrile

: 1432913-96-6
tert-butyl (5-(5-chloro-2-(4-(N-(2,4-dimethoxybenzyl)-N-(1,2,4-thiadiazol-5-yl)sulfamoyl)-2,5-difluorophenoxy)-phenyl)-benzo[d]isoxazol-3-yl)(methyl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetylhydroxamic acid; potassium tert-butylate / N,N-dimethyl-formamide

1.2: Reflux

2.1: dmap / tetrahydrofuran / 18 h / 20 °C

3.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane / 5 h / Reflux

4.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

5.1: potassium carbonate / dimethyl sulfoxide / 16 h / 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; acetylhydroxamic acid; potassium tert-butylate; sodium hydride; sodium carbonate; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil; 3.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/acsmedchemlett.5b00447

Reference yield:

: 455280-00-9
5-bromobenzo[d]isoxazol-3-amine

: 1432913-96-6
tert-butyl (5-(5-chloro-2-(4-(N-(2,4-dimethoxybenzyl)-N-(1,2,4-thiadiazol-5-yl)sulfamoyl)-2,5-difluorophenoxy)-phenyl)-benzo[d]isoxazol-3-yl)(methyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: dmap / tetrahydrofuran / 18 h / 20 °C

2: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane / 5 h / Reflux

3: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

4: potassium carbonate / dimethyl sulfoxide / 16 h / 20 °C

5: sodium hydride / N,N-dimethyl-formamide; mineral oil

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; sodium carbonate; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil; 2: |Suzuki-Miyaura Coupling;
DOI:10.1021/acsmedchemlett.5b00447