4-[5-(cyclopropylmethoxy)-1,3-benzodioxol-4-yl]-N-[(2S)-1-{4-[9-(3,4-dimethoxyphenyl)-6-oxo-7,8-diazaspiro[4.5]dec-8-en-7-yl]piperidin-1-yl}-1-oxo-3-(pyridin-3-yl)propan-2-yl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide

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Chemical Name:4-[5-(cyclopropylmethoxy)-1,3-benzodioxol-4-yl]-N-[(2S)-1-{4-[9-(3,4-dimethoxyphenyl)-6-oxo-7,8-diazaspiro[4.5]dec-8-en-7-yl]piperidin-1-yl}-1-oxo-3-(pyridin-3-yl)propan-2-yl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide
CAS No.:1416468-26-2
Molecular Formula:C₄₇H₅₀N₈O₈
Molecular Weight:854.963
Hs Code.:

4-[5-(cyclopropylmethoxy)-1,3-benzodioxol-4-yl]-N-[(2S)-1-{4-[9-(3,4-dimethoxyphenyl)-6-oxo-7,8-diazaspiro[4.5]dec-8-en-7-yl]piperidin-1-yl}-1-oxo-3-(pyridin-3-yl)propan-2-yl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide

Synonyms:4-[5-(cyclopropylmethoxy)-1,3-benzodioxol-4-yl]-N-[(2S)-1-{4-[9-(3,4-dimethoxyphenyl)-6-oxo-7,8-diazaspiro[4.5]dec-8-en-7-yl]piperidin-1-yl}-1-oxo-3-(pyridin-3-yl)propan-2-yl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide

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Chemical Property of 4-[5-(cyclopropylmethoxy)-1,3-benzodioxol-4-yl]-N-[(2S)-1-{4-[9-(3,4-dimethoxyphenyl)-6-oxo-7,8-diazaspiro[4.5]dec-8-en-7-yl]piperidin-1-yl}-1-oxo-3-(pyridin-3-yl)propan-2-yl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide

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Technology Process of 4-[5-(cyclopropylmethoxy)-1,3-benzodioxol-4-yl]-N-[(2S)-1-{4-[9-(3,4-dimethoxyphenyl)-6-oxo-7,8-diazaspiro[4.5]dec-8-en-7-yl]piperidin-1-yl}-1-oxo-3-(pyridin-3-yl)propan-2-yl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide

There total 7 articles about 4-[5-(cyclopropylmethoxy)-1,3-benzodioxol-4-yl]-N-[(2S)-1-{4-[9-(3,4-dimethoxyphenyl)-6-oxo-7,8-diazaspiro[4.5]dec-8-en-7-yl]piperidin-1-yl}-1-oxo-3-(pyridin-3-yl)propan-2-yl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1185837-25-5
4-[5-(cyclopropylmethoxy)-1,3-benzodioxol-4-yl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid

: 1416470-05-7
7-{1-[(2S)-2-amino-3-(pyridin-3-yl)propanoyl]piperidin-4-yl}-9-(3,4-dimethoxyphenyl)-7,8-diazaspiro[4.5]dec-8-en-6-one

: 1416468-26-2
4-[5-(cyclopropylmethoxy)-1,3-benzodioxol-4-yl]-N-[(2S)-1-{4-[9-(3,4-dimethoxyphenyl)-6-oxo-7,8-diazaspiro[4.5]dec-8-en-7-yl]piperidin-1-yl}-1-oxo-3-(pyridin-3-yl)propan-2-yl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide

Guidance literature:: 4-[5-(cyclopropylmethoxy)-1,3-benzodioxol-4-yl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.0833333h;

7-{1-[(2S)-2-amino-3-(pyridin-3-yl)propanoyl]piperidin-4-yl}-9-(3,4-dimethoxyphenyl)-7,8-diazaspiro[4.5]dec-8-en-6-one; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 91-16-7
1,2-dimethoxybenzene

: 1416468-26-2
4-[5-(cyclopropylmethoxy)-1,3-benzodioxol-4-yl]-N-[(2S)-1-{4-[9-(3,4-dimethoxyphenyl)-6-oxo-7,8-diazaspiro[4.5]dec-8-en-7-yl]piperidin-1-yl}-1-oxo-3-(pyridin-3-yl)propan-2-yl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: aluminum (III) chloride / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

2.1: triethylamine / 5 h / 160 °C / microwave irradiation

3.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 2 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 0.08 h / 20 °C

5.2: 3 h / 20 °C

With aluminum (III) chloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;

Reference yield:

: 5623-90-5
2-oxaspiro[4.4]nonane-1,3-dione

: 1416468-26-2
4-[5-(cyclopropylmethoxy)-1,3-benzodioxol-4-yl]-N-[(2S)-1-{4-[9-(3,4-dimethoxyphenyl)-6-oxo-7,8-diazaspiro[4.5]dec-8-en-7-yl]piperidin-1-yl}-1-oxo-3-(pyridin-3-yl)propan-2-yl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: aluminum (III) chloride / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

2.1: triethylamine / 5 h / 160 °C / microwave irradiation

3.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 2 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 0.08 h / 20 °C

5.2: 3 h / 20 °C

With aluminum (III) chloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;