(S)-(-)-2-[2-(6,7-dimethoxy-3,4-dihydroisoquinolin-3-yl)-4,5-dimethoxyphenyl]ethanol

Base Information

Chemical Name:(S)-(-)-2-[2-(6,7-dimethoxy-3,4-dihydroisoquinolin-3-yl)-4,5-dimethoxyphenyl]ethanol
CAS No.:406215-55-2
Molecular Formula:C₂₁H₂₅NO₅
Molecular Weight:371.433
Hs Code.:

Synonyms:(S)-(-)-2-[2-(6,7-dimethoxy-3,4-dihydroisoquinolin-3-yl)-4,5-dimethoxyphenyl]ethanol

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Chemical Property of (S)-(-)-2-[2-(6,7-dimethoxy-3,4-dihydroisoquinolin-3-yl)-4,5-dimethoxyphenyl]ethanol

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Technology Process of (S)-(-)-2-[2-(6,7-dimethoxy-3,4-dihydroisoquinolin-3-yl)-4,5-dimethoxyphenyl]ethanol

There total 9 articles about (S)-(-)-2-[2-(6,7-dimethoxy-3,4-dihydroisoquinolin-3-yl)-4,5-dimethoxyphenyl]ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 406215-71-2
4-methyl-benzenesulfinic acid [1-{2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4,5-dimethoxy-phenyl}-2-(2-cyano-4,5-dimethoxy-phenyl)-ethyl]-amide

: 406215-55-2
(S)-(-)-2-[2-(6,7-dimethoxy-3,4-dihydroisoquinolin-3-yl)-4,5-dimethoxyphenyl]ethanol

Guidance literature:: 4-methyl-benzenesulfinic acid [1-{2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4,5-dimethoxy-phenyl}-2-(2-cyano-4,5-dimethoxy-phenyl)-ethyl]-amide; With diisobutylaluminium hydride; In dichloromethane; at 0 ℃; for 2h;

With hydrogenchloride; for 0.25h; Further stages.;
DOI:10.1021/jo010988v

Reference yield:

: 494-99-5
1,2-dimethoxy-4-methylbenzene

: 406215-55-2
(S)-(-)-2-[2-(6,7-dimethoxy-3,4-dihydroisoquinolin-3-yl)-4,5-dimethoxyphenyl]ethanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 85 percent / N-bromosuccinimide / CHCl₃ / 4 h / Heating

2.1: 90 percent / dimethylformamide / 16 h / 120 °C

3.1: LDA / tetrahydrofuran / 0.5 h / -78 °C

3.2: 68 percent / tetrahydrofuran / 0.5 h / -78 °C

4.1: DIBAL-H / CH₂Cl₂ / 2 h / 0 °C

4.2: 70 percent / 3 N HCl / 0.25 h

With N-Bromosuccinimide; diisobutylaluminium hydride; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jo010988v

Reference yield:

: 52806-46-9
1-bromo-4,5-dimethoxy-2-methylbenzene

: 406215-55-2
(S)-(-)-2-[2-(6,7-dimethoxy-3,4-dihydroisoquinolin-3-yl)-4,5-dimethoxyphenyl]ethanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 90 percent / dimethylformamide / 16 h / 120 °C

2.1: LDA / tetrahydrofuran / 0.5 h / -78 °C

2.2: 68 percent / tetrahydrofuran / 0.5 h / -78 °C

3.1: DIBAL-H / CH₂Cl₂ / 2 h / 0 °C

3.2: 70 percent / 3 N HCl / 0.25 h

With diisobutylaluminium hydride; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo010988v