(2S,3S)-2-((R)-1-hydroxyethyl)-N-methoxy-N-methyl-4-nitro-3-phenylbutanamide

Base Information

Chemical Name:(2S,3S)-2-((R)-1-hydroxyethyl)-N-methoxy-N-methyl-4-nitro-3-phenylbutanamide
CAS No.:1643654-98-1
Molecular Formula:C₁₄H₂₀N₂O₅
Molecular Weight:296.323
Hs Code.:

Synonyms:(2S,3S)-2-((R)-1-hydroxyethyl)-N-methoxy-N-methyl-4-nitro-3-phenylbutanamide

Suppliers and Price of (2S,3S)-2-((R)-1-hydroxyethyl)-N-methoxy-N-methyl-4-nitro-3-phenylbutanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3S)-2-((R)-1-hydroxyethyl)-N-methoxy-N-methyl-4-nitro-3-phenylbutanamide

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Technology Process of (2S,3S)-2-((R)-1-hydroxyethyl)-N-methoxy-N-methyl-4-nitro-3-phenylbutanamide

There total 2 articles about (2S,3S)-2-((R)-1-hydroxyethyl)-N-methoxy-N-methyl-4-nitro-3-phenylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1643654-76-5
(2S,3S)-2-acetyl-N-methoxy-N-methyl-4-nitro-3-phenylbutanamide

: 1643654-98-1
(2S,3S)-2-((R)-1-hydroxyethyl)-N-methoxy-N-methyl-4-nitro-3-phenylbutanamide

: 1643654-95-8
(2S,3S)-2-((S)-1-hydroxyethyl)-N-methoxy-N-methyl-4-nitro-3-phenylbutanamide

Guidance literature:: With tetramethylammonium borohydride; In methanol; at -40 ℃; for 4h;
DOI:10.1002/chem.201402192

Reference yield:

: 133146-85-7
N-methoxy-N-methyl-3-oxobutanamide

: 1643654-98-1
(2S,3S)-2-((R)-1-hydroxyethyl)-N-methoxy-N-methyl-4-nitro-3-phenylbutanamide

: 1643654-95-8
(2S,3S)-2-((S)-1-hydroxyethyl)-N-methoxy-N-methyl-4-nitro-3-phenylbutanamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1-[3,5-bis(trifluoromethyl)phenyl]-3-[(1S,2S)-2-(dimethylamino)cyclohexyl]thiourea / dichloromethane / 28 h / 25 °C / Inert atmosphere

2: tetramethylammonium borohydride / methanol / 4 h / -40 °C

With 1-[3,5-bis(trifluoromethyl)phenyl]-3-[(1S,2S)-2-(dimethylamino)cyclohexyl]thiourea; tetramethylammonium borohydride; In methanol; dichloromethane;
DOI:10.1002/chem.201402192