(2S,3S)-2-((R)-1-((tert-butyldimethylsilyl)oxy)ethyl)-4-nitro-3-phenylbutanal

Base Information

Chemical Name:(2S,3S)-2-((R)-1-((tert-butyldimethylsilyl)oxy)ethyl)-4-nitro-3-phenylbutanal
CAS No.:1643654-97-0
Molecular Formula:C₁₈H₂₉NO₄Si
Molecular Weight:351.518
Hs Code.:

Synonyms:(2S,3S)-2-((R)-1-((tert-butyldimethylsilyl)oxy)ethyl)-4-nitro-3-phenylbutanal

Suppliers and Price of (2S,3S)-2-((R)-1-((tert-butyldimethylsilyl)oxy)ethyl)-4-nitro-3-phenylbutanal

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (2S,3S)-2-((R)-1-((tert-butyldimethylsilyl)oxy)ethyl)-4-nitro-3-phenylbutanal

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (2S,3S)-2-((R)-1-((tert-butyldimethylsilyl)oxy)ethyl)-4-nitro-3-phenylbutanal

There total 3 articles about (2S,3S)-2-((R)-1-((tert-butyldimethylsilyl)oxy)ethyl)-4-nitro-3-phenylbutanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1643654-99-2
(2S,3S)-2-((R)-1-((tert-butyldimethylsilyl)oxy)ethyl)-N-methoxy-N-methyl-4-nitro-3-phenylbutanamide

: (R,E)-2-(2-nitro-1-phenylethyl)but-2-enal

: 1643654-97-0
(2S,3S)-2-((R)-1-((tert-butyldimethylsilyl)oxy)ethyl)-4-nitro-3-phenylbutanal

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at -40 - 0 ℃; for 3h;
DOI:10.1002/chem.201402192

Reference yield:

: 1643654-76-5
(2S,3S)-2-acetyl-N-methoxy-N-methyl-4-nitro-3-phenylbutanamide

: (R,E)-2-(2-nitro-1-phenylethyl)but-2-enal

: 1643654-97-0
(2S,3S)-2-((R)-1-((tert-butyldimethylsilyl)oxy)ethyl)-4-nitro-3-phenylbutanal

Guidance literature:: Multi-step reaction with 3 steps

1: tetramethylammonium borohydride / methanol / 4 h / -40 °C

2: 1H-imidazole / dichloromethane / 48 h / 0 - 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / -40 - 0 °C

With 1H-imidazole; lithium aluminium tetrahydride; tetramethylammonium borohydride; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1002/chem.201402192

Reference yield:

: 1643654-98-1
(2S,3S)-2-((R)-1-hydroxyethyl)-N-methoxy-N-methyl-4-nitro-3-phenylbutanamide

: 18162-48-6
tert-butyldimethylsilyl chloride

: (R,E)-2-(2-nitro-1-phenylethyl)but-2-enal

: 1643654-97-0
(2S,3S)-2-((R)-1-((tert-butyldimethylsilyl)oxy)ethyl)-4-nitro-3-phenylbutanal

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-imidazole / dichloromethane / 48 h / 0 - 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / -40 - 0 °C

With 1H-imidazole; lithium aluminium tetrahydride; In tetrahydrofuran; dichloromethane;
DOI:10.1002/chem.201402192