6-bromo-N-(2,2-dimethoxy-ethyl)-N-(diphenyl-phosphinoylmethyl)-2,3-dimethoxy-benzamide

Base Information

• Chemical Name: 6-bromo-N-(2,2-dimethoxy-ethyl)-N-(diphenyl-phosphinoylmethyl)-2,3-dimethoxy-benzamide
• CAS No.: 265670-63-1
• Molecular Formula: C₂₆H₂₉BrNO₆P
• Molecular Weight: 562.397

Synonyms:6-bromo-N-(2,2-dimethoxy-ethyl)-N-(diphenyl-phosphinoylmethyl)-2,3-dimethoxy-benzamide

Chemical Property of 6-bromo-N-(2,2-dimethoxy-ethyl)-N-(diphenyl-phosphinoylmethyl)-2,3-dimethoxy-benzamide

Chemical Property:

Purity/Quality:

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Technology Process of 6-bromo-N-(2,2-dimethoxy-ethyl)-N-(diphenyl-phosphinoylmethyl)-2,3-dimethoxy-benzamide

There total 2 articles about 6-bromo-N-(2,2-dimethoxy-ethyl)-N-(diphenyl-phosphinoylmethyl)-2,3-dimethoxy-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-bromo-5,6-dimethoxybenzoyl chloride (64482-27-5) + N-[(diphenylphosphinyl)methyl]-N-(2-yl-acetaldehyde dimethylacetal) (265670-62-0) → 6-bromo-N-(2,2-dimethoxy-ethyl)-N-(diphenyl-phosphinoylmethyl)-2,3-dimethoxy-benzamide (265670-63-1)

Guidance literature:

With triethylamine; In dichloromethane;

DOI:10.1016/S0040-4020(00)00067-3

Reference yield:

Diphenylphosphine oxide (4559-70-0) → 6-bromo-N-(2,2-dimethoxy-ethyl)-N-(diphenyl-phosphinoylmethyl)-2,3-dimethoxy-benzamide (265670-63-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / toluene / 1 h / Heating

2: 86 percent / Et₃N / CH₂Cl₂

With triethylamine; In dichloromethane; toluene; 1: Substitution / 2: Condensation;

DOI:10.1016/S0040-4020(00)00067-3

Reference yield: 83.0%

6-bromo-N-(2,2-dimethoxy-ethyl)-N-(diphenyl-phosphinoylmethyl)-2,3-dimethoxy-benzamide (265670-63-1) → 7-bromo-2-(2,2-dimethoxy-ethyl)-3-(diphenyl-phosphinoyl)-4-methoxy-2,3-dihydro-isoindol-1-one

Guidance literature:

With potassium hexamethylsilazane; In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1016/S0040-4020(00)00067-3

upstream raw materials:

2-bromo-5,6-dimethoxybenzoyl chloride

N-[(diphenylphosphinyl)methyl]-N-(2-yl-acetaldehyde dimethylacetal)

Diphenylphosphine oxide

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