1-<5'-(L-phenylalanylmethylamino)-5'-deoxy-5'-cyano-α-L-talo-furanosyl>uracil

Base Information

Chemical Name:1-<5'-(L-phenylalanylmethylamino)-5'-deoxy-5'-cyano-α-L-talo-furanosyl>uracil
CAS No.:100682-95-9
Molecular Formula:C₂₀H₂₃N₅O₆
Molecular Weight:429.433
Hs Code.:

Synonyms:1-<5'-(L-phenylalanylmethylamino)-5'-deoxy-5'-cyano-α-L-talo-furanosyl>uracil

Suppliers and Price of 1-<5'-(L-phenylalanylmethylamino)-5'-deoxy-5'-cyano-α-L-talo-furanosyl>uracil

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-<5'-(L-phenylalanylmethylamino)-5'-deoxy-5'-cyano-α-L-talo-furanosyl>uracil

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Technology Process of 1-<5'-(L-phenylalanylmethylamino)-5'-deoxy-5'-cyano-α-L-talo-furanosyl>uracil

There total 6 articles about 1-<5'-(L-phenylalanylmethylamino)-5'-deoxy-5'-cyano-α-L-talo-furanosyl>uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 100683-01-0
[(S)-1-({(S)-Cyano-[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-methyl}-methyl-carbamoyl)-2-phenyl-ethyl]-carbamic acid benzyl ester

: 100682-95-9
1-<5'-(L-phenylalanylmethylamino)-5'-deoxy-5'-cyano-α-L-talo-furanosyl>uracil

Guidance literature:: With formic acid; palladium; In methanol; for 0.5h;
DOI:10.1021/jo00362a027

Reference yield:

: 1161-13-3
N-Cbz-L-Phe

: 100682-95-9
1-<5'-(L-phenylalanylmethylamino)-5'-deoxy-5'-cyano-α-L-talo-furanosyl>uracil

Guidance literature:: Multi-step reaction with 4 steps

1: N-methylmorpholine / CH₂Cl₂ / 2 h / -20 °C

2: CH₂Cl₂ / 16 h / -20 °C

3: 48 percent / 50 percent aq. HOAc / 3 h / Heating

4: 64 percent / HCO₂H / Pd black / methanol / 0.5 h

With 4-methyl-morpholine; formic acid; acetic acid; palladium; In methanol; dichloromethane;
DOI:10.1021/jo00362a027

Reference yield:

: 913971-35-4
bezyloxycarbonyl-L-phenylalanyl anhydride

: 100682-95-9
1-<5'-(L-phenylalanylmethylamino)-5'-deoxy-5'-cyano-α-L-talo-furanosyl>uracil

Guidance literature:: Multi-step reaction with 3 steps

1: CH₂Cl₂ / 16 h / -20 °C

2: 48 percent / 50 percent aq. HOAc / 3 h / Heating

3: 64 percent / HCO₂H / Pd black / methanol / 0.5 h

With formic acid; acetic acid; palladium; In methanol; dichloromethane;
DOI:10.1021/jo00362a027