4-(4-chloro-3-cyclopropylmethylsulfonyl-2-methylbenzoyl)-3-cyclopropyl-5-hydroxy-1-methylpyrazole

Base Information

Chemical Name:4-(4-chloro-3-cyclopropylmethylsulfonyl-2-methylbenzoyl)-3-cyclopropyl-5-hydroxy-1-methylpyrazole
CAS No.:1088713-11-4
Molecular Formula:C₁₉H₂₁ClN₂O₄S
Molecular Weight:408.906
Hs Code.:

Synonyms:4-(4-chloro-3-cyclopropylmethylsulfonyl-2-methylbenzoyl)-3-cyclopropyl-5-hydroxy-1-methylpyrazole

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Chemical Property of 4-(4-chloro-3-cyclopropylmethylsulfonyl-2-methylbenzoyl)-3-cyclopropyl-5-hydroxy-1-methylpyrazole

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Technology Process of 4-(4-chloro-3-cyclopropylmethylsulfonyl-2-methylbenzoyl)-3-cyclopropyl-5-hydroxy-1-methylpyrazole

There total 8 articles about 4-(4-chloro-3-cyclopropylmethylsulfonyl-2-methylbenzoyl)-3-cyclopropyl-5-hydroxy-1-methylpyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1088713-10-3
4-(4-chloro-3-cyclopropylmethylthio-2-methylbenzoyl)-3-cyclopropyl-5-hydroxy-1-methylpyrazole

: 1088713-11-4
4-(4-chloro-3-cyclopropylmethylsulfonyl-2-methylbenzoyl)-3-cyclopropyl-5-hydroxy-1-methylpyrazole

Guidance literature:: 4-(4-chloro-3-cyclopropylmethylthio-2-methylbenzoyl)-3-cyclopropyl-5-hydroxy-1-methylpyrazole; With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 5h;

With water; sodium hydrogensulfite; In dichloromethane;

Reference yield:

: 1088713-35-2
methyl 4-chloro-3-mercapto-2-methylbenzoate

: 1088713-11-4
4-(4-chloro-3-cyclopropylmethylsulfonyl-2-methylbenzoyl)-3-cyclopropyl-5-hydroxy-1-methylpyrazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / acetonitrile / 16 h / 20 °C

2.1: methanol; sodium hydroxide; water / 16 h / 20 °C

3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 16 h / 20 °C

3.2: 16 h / 20 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 5 h / 20 °C

With methanol; dmap; sodium hydroxide; water; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; acetonitrile;

Reference yield:

: 1088713-33-0
methyl 4-chloro-3-(dimethylaminocarbonylthio)-2-methyl-benzoate

: 1088713-11-4
4-(4-chloro-3-cyclopropylmethylsulfonyl-2-methylbenzoyl)-3-cyclopropyl-5-hydroxy-1-methylpyrazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: methanol; potassium hydroxide; water / 48 h / Heating / reflux

2.1: sulfuric acid / 17 h / Heating / reflux

3.1: caesium carbonate / acetonitrile / 16 h / 20 °C

4.1: methanol; sodium hydroxide; water / 16 h / 20 °C

5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 16 h / 20 °C

5.2: 16 h / 20 °C

6.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 5 h / 20 °C

With methanol; dmap; potassium hydroxide; sodium hydroxide; sulfuric acid; water; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; acetonitrile;