4-(4-chloro-3-cyclopropylmethylthio-2-methylbenzoyl)-3-cyclopropyl-5-hydroxy-1-methylpyrazole

Base Information

Chemical Name:4-(4-chloro-3-cyclopropylmethylthio-2-methylbenzoyl)-3-cyclopropyl-5-hydroxy-1-methylpyrazole
CAS No.:1088713-10-3
Molecular Formula:C₁₉H₂₁ClN₂O₂S
Molecular Weight:376.907
Hs Code.:

Synonyms:4-(4-chloro-3-cyclopropylmethylthio-2-methylbenzoyl)-3-cyclopropyl-5-hydroxy-1-methylpyrazole

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Chemical Property of 4-(4-chloro-3-cyclopropylmethylthio-2-methylbenzoyl)-3-cyclopropyl-5-hydroxy-1-methylpyrazole

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Technology Process of 4-(4-chloro-3-cyclopropylmethylthio-2-methylbenzoyl)-3-cyclopropyl-5-hydroxy-1-methylpyrazole

There total 7 articles about 4-(4-chloro-3-cyclopropylmethylthio-2-methylbenzoyl)-3-cyclopropyl-5-hydroxy-1-methylpyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 199125-21-8
3-(cyclopropyl)-1-methyl-1H-pyrazol-5-ol

: 1088713-37-4
4-chloro-3-cyclopropylmethylthio-2-methylbenzoic acid

: 1088713-10-3
4-(4-chloro-3-cyclopropylmethylthio-2-methylbenzoyl)-3-cyclopropyl-5-hydroxy-1-methylpyrazole

Guidance literature:: 3-cyclopropyl-1-methyl-1H-pyrazol-5-ol; 4-chloro-3-cyclopropylmethylthio-2-methylbenzoic acid; With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; at 20 ℃; for 16h;

With potassium cyanide; triethylamine; 2-hydroxy-2-methylpropanenitrile; In acetonitrile; at 20 ℃; for 16h;

Reference yield:

: 1088713-33-0
methyl 4-chloro-3-(dimethylaminocarbonylthio)-2-methyl-benzoate

: 1088713-10-3
4-(4-chloro-3-cyclopropylmethylthio-2-methylbenzoyl)-3-cyclopropyl-5-hydroxy-1-methylpyrazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: methanol; potassium hydroxide; water / 48 h / Heating / reflux

2.1: sulfuric acid / 17 h / Heating / reflux

3.1: caesium carbonate / acetonitrile / 16 h / 20 °C

4.1: methanol; sodium hydroxide; water / 16 h / 20 °C

5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 16 h / 20 °C

5.2: 16 h / 20 °C

With methanol; dmap; potassium hydroxide; sodium hydroxide; sulfuric acid; water; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile;

Reference yield:

: 1088713-35-2
methyl 4-chloro-3-mercapto-2-methylbenzoate

: 1088713-10-3
4-(4-chloro-3-cyclopropylmethylthio-2-methylbenzoyl)-3-cyclopropyl-5-hydroxy-1-methylpyrazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / acetonitrile / 16 h / 20 °C

2.1: methanol; sodium hydroxide; water / 16 h / 20 °C

3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 16 h / 20 °C

3.2: 16 h / 20 °C

With methanol; dmap; sodium hydroxide; water; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile;