7-Methoxyquinolin-4-amine

Base Information

• Chemical Name: 7-Methoxyquinolin-4-amine
• CAS No.: 103040-78-4
• Molecular Formula: C10H10N2O
• Molecular Weight: 174.202
• Hs Code.: 2933499090
• European Community (EC) Number: 800-468-3
• ChEMBL ID: CHEMBL2393329
• DSSTox Substance ID: DTXSID50589052
• Nikkaji Number: J2.571.284F
• Wikidata: Q82482165
• Mol file: 103040-78-4.mol

Synonyms:4-Amino-7-methoxylquinoline;103040-78-4;7-methoxyquinolin-4-amine;4-Amino-7-methoxyquinoline;MFCD08063213;SCHEMBL3841526;CHEMBL2393329;DTXSID50589052;DZXVXEFSGHJKHI-UHFFFAOYSA-N;BBL030899;STL248939;AKOS005142021;AB43461;MCULE-3444308674;SB68280;SY227414;VS-10106;DB-006648;CS-0107018;D76682;A853255

Chemical Property of 7-Methoxyquinolin-4-amine

Chemical Property:

• Vapor Pressure: 1.17E-05mmHg at 25°C
• Refractive Index: 1.664
• Boiling Point: 369.649 °C at 760 mmHg
• Flash Point: 177.357 °C
• PSA: 48.14000
• Density: 1.218 g/cm³
• LogP: 2.40680
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 174.079312947
• Heavy Atom Count: 13
• Complexity: 174

Purity/Quality:

97% ^*data from raw suppliers

4-Amino-7-methoxyquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC2=NC=CC(=C2C=C1)N

Technology Process of 7-Methoxyquinolin-4-amine

There total 10 articles about 7-Methoxyquinolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

7-methoxy-4-hydrazinoquinoline (49612-23-9) → 7-methoxy-quinolin-4-ylamine (103040-78-4)

Guidance literature:

With sodium tetrahydroborate; nickel dichloride; In methanol; at 20 ℃; for 5h;

DOI:10.1016/j.tetlet.2008.01.128

Reference yield:

4-hydroxy-7-methoxyquinoline (82121-05-9) → 7-methoxy-quinolin-4-ylamine (103040-78-4)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / 0.33 h / 140 °C

2: ammonium hydroxide; zinc(II) chloride / 1.5 h / 160 - 180 °C / 15376.5 Torr / Microwave irradiation

With ammonium hydroxide; zinc(II) chloride; trichlorophosphate;

DOI:10.1016/j.bmc.2013.04.040

Reference yield:

7-methoxy-4-nitro-quinoline (103754-61-6) → 7-methoxy-quinolin-4-ylamine (103040-78-4)

Guidance literature:

With methanol; nickel; at 80 ℃; under 18387.7 Torr; Hydrogenation;

upstream raw materials:

7-methoxy-4-nitro-quinoline

7-methoxy-4-hydrazinoquinoline

m-Anisidine

Diethyl 2-<(3-methoxyphenylamino)methylene>malonate

Downstream raw materials:

1-(4-N,N-dimethylaminophenyl)-3-(7-methoxy)quinolin-4-ylurea hydrochloride