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82121-05-9

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82121-05-9 Usage

Description

4-Hydroxy-7-methoxyquinoline is a solid substance and it is a useful research chemical.

Uses

7-Methoxy-4-quinolinol is a heterocyclic organic compound and can be used as a pharmaceutical intermediate.

Check Digit Verification of cas no

The CAS Registry Mumber 82121-05-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,2,1,2 and 1 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 82121-05:
(7*8)+(6*2)+(5*1)+(4*2)+(3*1)+(2*0)+(1*5)=89
89 % 10 = 9
So 82121-05-9 is a valid CAS Registry Number.
InChI:InChI=1/C9H8N2O2/c1-13-6-2-3-7-8(4-6)11-10-5-9(7)12/h2-5H,1H3,(H,11,12)

82121-05-9 Well-known Company Product Price

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  • Aldrich

  • (699896)  4-Hydroxy-7-methoxyquinoline  97%

  • 82121-05-9

  • 699896-5G

  • 1,065.87CNY

  • Detail

82121-05-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-Hydroxy-7-methoxyquinoline

1.2 Other means of identification

Product number -
Other names 7-Methoxy-4-quinolinol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:82121-05-9 SDS

82121-05-9Relevant articles and documents

Design, synthesis, structure-activity relationships and mechanism of action of new quinoline derivatives as potential antitumor agents

Li, Shangze,Hu, Lihua,Li, Jianru,Zhu, Jiongchang,Zeng, Feng,Huang, Qiuhua,Qiu, Liqin,Du, Runlei,Cao, Rihui

, p. 666 - 678 (2018/11/30)

A series of new quinoline derivatives was designed, synthesized and evaluated as potential antitumor agents. The results indicated that most compounds exhibited potent antiproliferative activity, and 7-(4-fluorobenzyloxy)–N-(2-(dimethylamino)- ethyl)quinolin-4-amine 10g was found to be the most potent antiproliferative agent against human tumor cell lines with an IC50 value of less than 1.0 μM. Preliminary structure-activity relationships analysis suggested that (1) the large and bulky alkoxy substituent in position-7 might be a beneficial pharmacophoric group for antiproliferative activity; (2) the amino side chain substituents in position-4 facilitated the antiproliferative activity of this class of compounds; and (3) the length of the alkylamino side chain moiety affected the antiproliferative potency, with two CH2 units being the most favorable. Further investigation of the mechanism of action of this class of compounds demonstrated that the representative compound 10g triggered p53/Bax-dependent colorectal cancer cell apoptosis by activating p53 transcriptional activity. Moreover, the results showed that compound 10g effectively inhibited tumor growth in a colorectal cancer xenograft model in nude mice. Thus, these quinoline derivatives might serve as candidates for the development of new antitumor drugs.

PROCESS FOR PREPARING SUBSTITUTED QUINOLIN-4-OL COMPOUNDS

-

Paragraph 0087, (2018/03/01)

The invention relates to a process for preparing substituted quinolin-4-ol compounds useful for preparing protein tyrosine kinase (PTK) inhibitors which are useful in treating cancer.

For antibacterial chlorine oxygen kui derivatives

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Paragraph 0172-0173; 0193-0194; 0201-0202, (2017/08/29)

The invention relates to an oxo-quinoline derivative with activity of resisting bacterial infection relevant diseases such as helicobacter pylori (Hp) infection disease. The invention specifically relates to a compound as shown in formula I in the specification, and a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein R is selected from hydrogen, -C alkyl, -C alkenyl, -C alkynyl, or -C alkyl-phenyl, and the alkyl, alkenyl, alkynyl and phenyl can be randomly substituted by halogen, nitro, cyan, hydroxyl, -C alkoxy and phenyl; R is selected from hydrogen, -CONHR and -COOR, R and R are independently selected from -C alkyl and -C alkyl amino, and the amino is randomly substituted by one to two -C alkyls; R is selected from halogen, -C alkoxy, morpholinyl or piperazinyl.

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