5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-2-NAPHTHALENECARBOXYLIC ACID

Base Information

• Chemical Name: 5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-2-NAPHTHALENECARBOXYLIC ACID
• CAS No.: 103031-30-7
• Molecular Formula: C15H20 O2
• Molecular Weight: 232.323
• Hs Code.: 2916399090
• Mol file: 103031-30-7.mol

Synonyms:2-Naphthoicacid, 5,6,7,8-tetrahydro-5,5,8,8-tetramethyl- (6CI);5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-2-naphthoic acid;5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid;5,6,7,8-Tetrahydro-5,5,8,8-tetramethylnaphthalene-2-carboxylic acid; NSC 19537

Chemical Property of 5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-2-NAPHTHALENECARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 2.23E-05mmHg at 25°C
• Melting Point: 197℃
• Refractive Index: 1.52
• Boiling Point: 346.1°Cat760mmHg
• Flash Point: 165.9°C
• PSA: 37.30000
• Density: 1.029g/cm³
• LogP: 3.73380
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

5,5,8,8-Tetramethyl-5,6,7,8-Tetrahydronaphthalene-2-CarboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:Irritating to eyes, respiratory system and skin.
• Hazard Codes: Xi:Irritant
• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S37/39:Wear suitable g

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5,5,8,8-Tetramethyl-5,6,7,8-Tetrahydronaphthalene-2-Carboxylic Acid is used in preparation of Tetrahydronaphthalenesulfonamides as CYP26 enzyme inhibitors.

Technology Process of 5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-2-NAPHTHALENECARBOXYLIC ACID

There total 7 articles about 5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-2-NAPHTHALENECARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene (6683-48-3) → 5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene-2-carboxaldehyde (92654-79-0) + 5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene-2-carboxylic acid (103031-30-7)

Guidance literature:

With ammonium cerium(IV) nitrate; acetic acid; at 100 ℃; for 0.25h;

DOI:10.1021/jm00127a018

Reference yield: 63.3%

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene (6683-48-3) → 5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene-2-carboxylic acid (103031-30-7)

Guidance literature:

With potassium permanganate; sodium hydroxide; In water; chlorobenzene; at 100 ℃; for 16h;

Reference yield:

5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid 7-oxo-4-[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-amino]-cyclohepta-1,3,5-trienyl ester (343962-13-0) → 5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene-2-carboxylic acid (103031-30-7) + Tp80 (343962-09-4)

Guidance literature:

5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid 7-oxo-4-[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-amino]-cyclohepta-1,3,5-trienyl ester; With sodium hydroxide; In ethanol; dichloromethane; water; at 20 ℃; for 20h;

With hydrogenchloride; In ethanol; dichloromethane; water;

upstream raw materials:

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene

2,5-dichloro-2,5-dimethyl hexane

toluene

5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid 7-oxo-4-[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-amino]-cyclohepta-1,3,5-trienyl ester

Downstream raw materials:

5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthylamine

methyl 4-<(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphalenyl)carboxamido>benzoate

5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphtholyl chloride

Ethyl-2-fluoro-4-[(5',6',7',8'-tetrahydro-5',5',8',8'-tetramethylnaphtalen-2'-yl)carbamoyl]benzoate

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