cyclo2-Boc-N³-Troc-(R)-aminoala-L-Leu-D-β-Me-iso-Asp(OMe)-L-Ala>

Base Information

Chemical Name:cyclo2-Boc-N³-Troc-(R)-aminoala-L-Leu-D-β-Me-iso-Asp(OMe)-L-Ala>
CAS No.:225781-03-3
Molecular Formula:C₅₁H₇₃Cl₃N₈O₁₄
Molecular Weight:1128.54
Hs Code.:

cyclo<Adda-D-iso-Glu(OMe)-MeΔAla-N<sup>2</sup>-Boc-N<sup>3</sup>-Troc-(R)-aminoala-L-Leu-D-β-Me-iso-Asp(OMe)-L-Ala>

Synonyms:cyclo2-Boc-N³-Troc-(R)-aminoala-L-Leu-D-β-Me-iso-Asp(OMe)-L-Ala>

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Chemical Property of cyclo2-Boc-N³-Troc-(R)-aminoala-L-Leu-D-β-Me-iso-Asp(OMe)-L-Ala>

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Technology Process of cyclo2-Boc-N³-Troc-(R)-aminoala-L-Leu-D-β-Me-iso-Asp(OMe)-L-Ala>

There total 6 articles about cyclo2-Boc-N³-Troc-(R)-aminoala-L-Leu-D-β-Me-iso-Asp(OMe)-L-Ala> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 184353-93-3
(2R,3S)-2-[Benzyl-(9-phenyl-9H-fluoren-9-yl)-amino]-3-methyl-succinic acid 1-methyl ester

: 225781-03-3
cyclo2-Boc-N³-Troc-(R)-aminoala-L-Leu-D-β-Me-iso-Asp(OMe)-L-Ala>

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / HATU, iPr₂NEt / dimethylformamide / 1.) 0 deg C, 3 h, 2.) room temperature, 12 h

2: 1.) H₂, TFA, 2.) HATU, collidine / 1.) 10 percent Pd/C / 1.) MeOH, 1 atm, 13 h, 2.) 0 deg C, 2 h; room temperature, 16 h

3: 1.) HOAt, DCC, 2.) TFA, 3.) collidine / 1.) DMF, CH₂Cl₂, 0 deg C, 2 h; room temperature, 7 h, 2.) 1.5 h, 3.) DMF, 0 deg C, 4 h; room temperature, 12 h

4: 1.) pentafluorophenol, DCC, 2.) TFA, 3.) phosphate buffer / 1.) EtOAc, 0 deg C, 1.5 h; room temperature, 6.5 h, 2.) 20 min, 3.) pH 9.5, 30 min

With 2,3,5-trimethyl-pyridine; 1-hydroxy-7-aza-benzotriazole; phosphate buffer; 2,3,4,5,6-pentafluorophenol; hydrogen; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; palladium on activated charcoal; In N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(98)00254-5

Reference yield:

: 225780-70-1
D-erythro-N-(9-phenylfluoren-9-yl)-N-benzyl-β-Me-iso-Asp(OMe)-L-Ala-OtBu

: 225781-03-3
cyclo2-Boc-N³-Troc-(R)-aminoala-L-Leu-D-β-Me-iso-Asp(OMe)-L-Ala>

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) H₂, TFA, 2.) HATU, collidine / 1.) 10 percent Pd/C / 1.) MeOH, 1 atm, 13 h, 2.) 0 deg C, 2 h; room temperature, 16 h

2: 1.) HOAt, DCC, 2.) TFA, 3.) collidine / 1.) DMF, CH₂Cl₂, 0 deg C, 2 h; room temperature, 7 h, 2.) 1.5 h, 3.) DMF, 0 deg C, 4 h; room temperature, 12 h

3: 1.) pentafluorophenol, DCC, 2.) TFA, 3.) phosphate buffer / 1.) EtOAc, 0 deg C, 1.5 h; room temperature, 6.5 h, 2.) 20 min, 3.) pH 9.5, 30 min

With 2,3,5-trimethyl-pyridine; 1-hydroxy-7-aza-benzotriazole; phosphate buffer; 2,3,4,5,6-pentafluorophenol; hydrogen; dicyclohexyl-carbodiimide; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; palladium on activated charcoal;
DOI:10.1016/S0968-0896(98)00254-5

Reference yield:

: 225780-95-0
Boc-D-iso-Glu(OMe)-MeδAla-N²-Boc-N³-Troc-(R)-aminoala-L-Leu-OH

: 225781-03-3
cyclo2-Boc-N³-Troc-(R)-aminoala-L-Leu-D-β-Me-iso-Asp(OMe)-L-Ala>

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) H₂, TFA, 2.) HATU, collidine / 1.) 10 percent Pd/C / 1.) MeOH, 1 atm, 13 h, 2.) 0 deg C, 2 h; room temperature, 16 h

2: 1.) HOAt, DCC, 2.) TFA, 3.) collidine / 1.) DMF, CH₂Cl₂, 0 deg C, 2 h; room temperature, 7 h, 2.) 1.5 h, 3.) DMF, 0 deg C, 4 h; room temperature, 12 h

3: 1.) pentafluorophenol, DCC, 2.) TFA, 3.) phosphate buffer / 1.) EtOAc, 0 deg C, 1.5 h; room temperature, 6.5 h, 2.) 20 min, 3.) pH 9.5, 30 min

With 2,3,5-trimethyl-pyridine; 1-hydroxy-7-aza-benzotriazole; phosphate buffer; 2,3,4,5,6-pentafluorophenol; hydrogen; dicyclohexyl-carbodiimide; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; palladium on activated charcoal;
DOI:10.1016/S0968-0896(98)00254-5