{2-[4-(2-Ethoxymethoxy-ethyl)-4-hydroxy-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-11-yl]-ethyl}-isopropyl-carbamic acid benzyl ester

Base Information

Chemical Name:{2-[4-(2-Ethoxymethoxy-ethyl)-4-hydroxy-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-11-yl]-ethyl}-isopropyl-carbamic acid benzyl ester
CAS No.:213129-98-7
Molecular Formula:C₃₆H₃₉N₃O₈
Molecular Weight:641.721
Hs Code.:

{2-[4-(2-Ethoxymethoxy-ethyl)-4-hydroxy-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-11-yl]-ethyl}-isopropyl-carbamic acid benzyl ester

Synonyms:{2-[4-(2-Ethoxymethoxy-ethyl)-4-hydroxy-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-11-yl]-ethyl}-isopropyl-carbamic acid benzyl ester

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Chemical Property of {2-[4-(2-Ethoxymethoxy-ethyl)-4-hydroxy-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-11-yl]-ethyl}-isopropyl-carbamic acid benzyl ester

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Technology Process of {2-[4-(2-Ethoxymethoxy-ethyl)-4-hydroxy-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-11-yl]-ethyl}-isopropyl-carbamic acid benzyl ester

There total 4 articles about {2-[4-(2-Ethoxymethoxy-ethyl)-4-hydroxy-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-11-yl]-ethyl}-isopropyl-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 213129-96-5
{2-[4-Hydroxy-4-(2-hydroxy-ethyl)-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-11-yl]-ethyl}-isopropyl-carbamic acid benzyl ester

: 3188-13-4
ethyl chloromethyl ether

: 213129-98-7
{2-[4-(2-Ethoxymethoxy-ethyl)-4-hydroxy-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-11-yl]-ethyl}-isopropyl-carbamic acid benzyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 44h;
DOI:10.1016/S0960-894X(98)00317-5

Reference yield:

: 177611-73-3
C₁₅H₁₇NO₇

: 213129-98-7
{2-[4-(2-Ethoxymethoxy-ethyl)-4-hydroxy-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-11-yl]-ethyl}-isopropyl-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / DMAP, pyridine / CH₂Cl₂ / 15 h / Ambient temperature

2: 89 percent / TFA / 4 h / Ambient temperature

3: 1.) p-TsOH, 2.) aq. LiOH, 2.) 1N HCl

4: 52 percent / i-Pr₂NEt / CH₂Cl₂ / 44 h / 0 - 20 °C

With pyridine; hydrogenchloride; dmap; lithium hydroxide; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/S0960-894X(98)00317-5

Reference yield:

: 213129-95-4
Acetic acid 4-(2-acetoxy-ethyl)-3,6,10-trioxo-3,4,6,7,8,10-hexahydro-1H-pyrano[3,4-f]indolizin-4-yl ester

: 213129-98-7
{2-[4-(2-Ethoxymethoxy-ethyl)-4-hydroxy-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-11-yl]-ethyl}-isopropyl-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) p-TsOH, 2.) aq. LiOH, 2.) 1N HCl

2: 52 percent / i-Pr₂NEt / CH₂Cl₂ / 44 h / 0 - 20 °C

With hydrogenchloride; lithium hydroxide; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1016/S0960-894X(98)00317-5