{2-[4-Hydroxy-4-(2-hydroxy-ethyl)-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-11-yl]-ethyl}-isopropyl-carbamic acid benzyl ester

Base Information

• Chemical Name: {2-[4-Hydroxy-4-(2-hydroxy-ethyl)-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-11-yl]-ethyl}-isopropyl-carbamic acid benzyl ester
• CAS No.: 213129-96-5
• Molecular Formula: C₃₃H₃₃N₃O₇
• Molecular Weight: 583.641
• Mol file: 213129-96-5.mol

Synonyms:{2-[4-Hydroxy-4-(2-hydroxy-ethyl)-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-11-yl]-ethyl}-isopropyl-carbamic acid benzyl ester

Chemical Property of {2-[4-Hydroxy-4-(2-hydroxy-ethyl)-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-11-yl]-ethyl}-isopropyl-carbamic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {2-[4-Hydroxy-4-(2-hydroxy-ethyl)-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-11-yl]-ethyl}-isopropyl-carbamic acid benzyl ester

There total 3 articles about {2-[4-Hydroxy-4-(2-hydroxy-ethyl)-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-11-yl]-ethyl}-isopropyl-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C15H17NO7 (177611-73-3) → {2-[4-Hydroxy-4-(2-hydroxy-ethyl)-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-11-yl]-ethyl}-isopropyl-carbamic acid benzyl ester (213129-96-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 94 percent / DMAP, pyridine / CH₂Cl₂ / 15 h / Ambient temperature

2: 89 percent / TFA / 4 h / Ambient temperature

3: 1.) p-TsOH, 2.) aq. LiOH, 2.) 1N HCl

With pyridine; hydrogenchloride; dmap; lithium hydroxide; toluene-4-sulfonic acid; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/S0960-894X(98)00317-5

Reference yield:

C19H21NO9 (213129-94-3) → {2-[4-Hydroxy-4-(2-hydroxy-ethyl)-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-11-yl]-ethyl}-isopropyl-carbamic acid benzyl ester (213129-96-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / TFA / 4 h / Ambient temperature

2: 1.) p-TsOH, 2.) aq. LiOH, 2.) 1N HCl

With hydrogenchloride; lithium hydroxide; toluene-4-sulfonic acid; trifluoroacetic acid;

DOI:10.1016/S0960-894X(98)00317-5

Reference yield:

[3-(2-Amino-phenyl)-3-oxo-propyl]-isopropyl-carbamic acid benzyl ester (177611-40-4) + Acetic acid 4-(2-acetoxy-ethyl)-3,6,10-trioxo-3,4,6,7,8,10-hexahydro-1H-pyrano[3,4-f]indolizin-4-yl ester (213129-95-4) → {2-[4-Hydroxy-4-(2-hydroxy-ethyl)-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-11-yl]-ethyl}-isopropyl-carbamic acid benzyl ester (213129-96-5)

Guidance literature:

With hydrogenchloride; lithium hydroxide; toluene-4-sulfonic acid; Multistep reaction;

DOI:10.1016/S0960-894X(98)00317-5

upstream raw materials:

[3-(2-Amino-phenyl)-3-oxo-propyl]-isopropyl-carbamic acid benzyl ester

Acetic acid 4-(2-acetoxy-ethyl)-3,6,10-trioxo-3,4,6,7,8,10-hexahydro-1H-pyrano[3,4-f]indolizin-4-yl ester

C₁₅H₁₇NO₇

C₁₉H₂₁NO₉

Downstream raw materials:

{2-[4-(2-Ethoxymethoxy-ethyl)-4-hydroxy-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-11-yl]-ethyl}-isopropyl-carbamic acid benzyl ester

{2-[4-Hydroxy-4-(2-methoxymethoxy-ethyl)-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-11-yl]-ethyl}-isopropyl-carbamic acid benzyl ester