6-Methoxy-2,3-dihydro-1H-inden-1-amine

Base Information

• Chemical Name: 6-Methoxy-2,3-dihydro-1H-inden-1-amine
• CAS No.: 103028-81-5
• Molecular Formula: C10H13NO
• Molecular Weight: 163.22
• Hs Code.: 2922199090
• DSSTox Substance ID: DTXSID40432785
• Mol file: 103028-81-5.mol

Synonyms:103028-81-5;6-Methoxy-2,3-dihydro-1H-inden-1-amine;6-Methoxy-1-Indanamine;6-methoxyindan-1-ylamine;6-methoxyindan-1-amine;2,3-DIHYDRO-6-METHOXY-1H-INDEN-1-AMINE;6-methoxy-1-aminoindan;6-METHOXY-1-AMINOINDAN HYDROCHLORIDE;6-METHOXY-INDAN-1-YL AMINE;1H-Inden-1-amine,2,3-dihydro-6-methoxy;1-Amino-6-methoxy indan;1-amino-6-methoxy-indane;SCHEMBL269087;DTXSID40432785;VYGIPIBKCOYHFK-UHFFFAOYSA-N;6-methoxy-1-indanamine, AldrichCPR;AM9619;MFCD04972430;AKOS000195680;AKOS016842854;AB21023;PB18777;PB26238;AC-13155;CS-0440030;FT-0660337;FT-0771203;FT-0773345;EN300-1232065;A853014;J-000860

Chemical Property of 6-Methoxy-2,3-dihydro-1H-inden-1-amine

Chemical Property:

• Vapor Pressure: 0.009mmHg at 25°C
• Refractive Index: 1.562
• Boiling Point: 266.116 °C at 760 mmHg
• PKA: 9.18±0.20(Predicted)
• Flash Point: 118.798 °C
• PSA: 35.25000
• Density: 1.087 g/cm³
• LogP: 2.34150
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 163.099714038
• Heavy Atom Count: 12
• Complexity: 160

Purity/Quality:

98%min ^*data from raw suppliers

6-Methoxy-2,3-dihydro-1H-inden-1-amine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC2=C(CCC2N)C=C1

Technology Process of 6-Methoxy-2,3-dihydro-1H-inden-1-amine

There total 8 articles about 6-Methoxy-2,3-dihydro-1H-inden-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

N-(6-methoxy-indan-1-yl)-acetamide → 6-methoxyindan-1-ylamine (103028-81-5,180915-77-9,354813-77-7,354813-79-9)

Guidance literature:

N-(6-methoxy-indan-1-yl)-acetamide; With hydrogenchloride; In methanol; water; at 25 - 90 ℃; for 21h; Heating / reflux;

With sodium hydroxide; In methanol; water; toluene; xylenes; at 22 ℃; pH=12 - 13;

Reference yield: 24.0%

(1S,2S)-1-Azido-2-bromo-6-methoxy-indan → 6-methoxyindan-1-ylamine (103028-81-5,180915-77-9,354813-77-7,354813-79-9)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 3h; Ambient temperature;

DOI:10.1021/jo00385a001

Reference yield:

6-methoxy-2,3-dihydro-1H-inden-1-one (13623-25-1) → 6-methoxyindan-1-ylamine (103028-81-5,180915-77-9,354813-77-7,354813-79-9)

Guidance literature:

With ammonium acetate; sodium cyanoborohydride;

DOI:10.1021/jo052621m

upstream raw materials:

6-methoxyindan-1-one oxime

acetic acid

6-methoxy-2,3-dihydro-1H-inden-1-one

5-methoxy-1H-indene

Downstream raw materials:

1-amino-6-hydroxyindan

Refernces

• 1、 Herzig, Yaacov,Lerman, Lena,Goldenberg, Willy,Lerner, David,Gottlieb, Hugo E.,Nudelman, Abraham. "Hydroxy-1-aminoindans and derivatives: Preparation, stability, and reactivity". . p. 4130 - 4140. Retrieved 2006.
• 2、 -. "SUBSTITUTED FLUOROETHYL UREAS AS ALPHA 2 ADRENERGIC AGENTS". Page/Page column 16. . Retrieved 2008/12/04.