{(2R,3S,5R)-3-[(tert-butoxycarbonyl)amino]-2-(2,5-difiuorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]piperidin-1-yl}acetic acid

Base Information

Chemical Name:{(2R,3S,5R)-3-[(tert-butoxycarbonyl)amino]-2-(2,5-difiuorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]piperidin-1-yl}acetic acid
CAS No.:1280211-10-0
Molecular Formula:C₂₄H₃₁F₂N₅O₆S
Molecular Weight:555.603
Hs Code.:

{(2R,3S,5R)-3-[(tert-butoxycarbonyl)amino]-2-(2,5-difiuorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]piperidin-1-yl}acetic acid

Synonyms:{(2R,3S,5R)-3-[(tert-butoxycarbonyl)amino]-2-(2,5-difiuorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]piperidin-1-yl}acetic acid

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Chemical Property of {(2R,3S,5R)-3-[(tert-butoxycarbonyl)amino]-2-(2,5-difiuorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]piperidin-1-yl}acetic acid

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Technology Process of {(2R,3S,5R)-3-[(tert-butoxycarbonyl)amino]-2-(2,5-difiuorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]piperidin-1-yl}acetic acid

There total 9 articles about {(2R,3S,5R)-3-[(tert-butoxycarbonyl)amino]-2-(2,5-difiuorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]piperidin-1-yl}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1280210-88-9
tert-butyl {(2R,3S,5R)-2-(2,5-difiuorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]piperidin-3-yl}carbamate

: 79-08-3
bromoacetic acid

: 1280211-10-0
{(2R,3S,5R)-3-[(tert-butoxycarbonyl)amino]-2-(2,5-difiuorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]piperidin-1-yl}acetic acid

Guidance literature:: In acetonitrile; for 192h;

Reference yield:

: 2646-90-4
2,5-difluorobenzaldehyde

: 1280211-10-0
{(2R,3S,5R)-3-[(tert-butoxycarbonyl)amino]-2-(2,5-difiuorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]piperidin-1-yl}acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: ammonium acetate / ethanol / 16 h / Reflux

2.1: sodium tetrahydroborate / nickel (II) chloride hexahydrate / methanol / 1 h / 0 °C

2.2: 15 h / 0 - 20 °C

3.1: N,N,N,N,-tetramethylethylenediamine; trimethylsilyl iodide / dichloromethane / 2 h / 0 °C

3.2: 3 h

3.3: 0.17 h

4.1: N,N,N,N,-tetramethylethylenediamine / dichloromethane; N,N-dimethyl-formamide / 64 h / 20 °C

5.1: dimethylsulfide borane complex / tetrahydrofuran / 1.25 h / 70 °C

5.2: 0.75 h / 0 °C

6.1: acetonitrile / 192 h

With sodium tetrahydroborate; trimethylsilyl iodide; N,N,N,N,-tetramethylethylenediamine; dimethylsulfide borane complex; ammonium acetate; nickel (II) chloride hexahydrate; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1280210-82-3
(5S,6R)-6-(2,5-difluorophenyl)-5-nitropiperidin-2-one

: 1280211-10-0
{(2R,3S,5R)-3-[(tert-butoxycarbonyl)amino]-2-(2,5-difiuorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]piperidin-1-yl}acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate / nickel (II) chloride hexahydrate / methanol / 1 h / 0 °C

1.2: 15 h / 0 - 20 °C

2.1: N,N,N,N,-tetramethylethylenediamine; trimethylsilyl iodide / dichloromethane / 2 h / 0 °C

2.2: 3 h

2.3: 0.17 h

3.1: N,N,N,N,-tetramethylethylenediamine / dichloromethane; N,N-dimethyl-formamide / 64 h / 20 °C

4.1: dimethylsulfide borane complex / tetrahydrofuran / 1.25 h / 70 °C

4.2: 0.75 h / 0 °C

5.1: acetonitrile / 192 h

With sodium tetrahydroborate; trimethylsilyl iodide; N,N,N,N,-tetramethylethylenediamine; dimethylsulfide borane complex; nickel (II) chloride hexahydrate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;