N⁶-benzoyl-9-[(2'S,3'R)-2',3'-dihydroxy-4'-(4,4'-dimethoxytrityloxy)butyl]adenine

Base Information

• Chemical Name: N⁶-benzoyl-9-[(2'S,3'R)-2',3'-dihydroxy-4'-(4,4'-dimethoxytrityloxy)butyl]adenine
• CAS No.: 765912-07-0
• Molecular Formula: C₃₇H₃₅N₅O₆
• Molecular Weight: 645.715

Synonyms:N⁶-benzoyl-9-[(2'S,3'R)-2',3'-dihydroxy-4'-(4,4'-dimethoxytrityloxy)butyl]adenine

Chemical Property of N⁶-benzoyl-9-[(2'S,3'R)-2',3'-dihydroxy-4'-(4,4'-dimethoxytrityloxy)butyl]adenine

Chemical Property:

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Technology Process of N⁶-benzoyl-9-[(2'S,3'R)-2',3'-dihydroxy-4'-(4,4'-dimethoxytrityloxy)butyl]adenine

There total 5 articles about N⁶-benzoyl-9-[(2'S,3'R)-2',3'-dihydroxy-4'-(4,4'-dimethoxytrityloxy)butyl]adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + N6-benzoyl-9-[(2'S,3'R)-2',3',4'-trihydroxybutyl]adenine (765912-05-8) → N6-benzoyl-9-[(2'S,3'R)-2',3'-dihydroxy-4'-(4,4'-dimethoxytrityloxy)butyl]adenine (765912-07-0)

Guidance literature:

With pyridine; at 20 ℃;

DOI:10.1016/j.bmcl.2004.06.071

Reference yield:

benzoyl chloride (98-88-4) → N6-benzoyl-9-[(2'S,3'R)-2',3'-dihydroxy-4'-(4,4'-dimethoxytrityloxy)butyl]adenine (765912-07-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: pyridine / 20 °C

1.2: pyridine / 20 °C

2.1: aq. AcOH / 60 °C

3.1: 94 percent / pyridine / 20 °C

With pyridine; acetic acid;

DOI:10.1016/j.bmcl.2004.06.071

Reference yield:

9-[(2'S,3'R)-4'-hydroxy-2',3'-isopropylidenedioxybutyl]adenine (81739-09-5) → N6-benzoyl-9-[(2'S,3'R)-2',3'-dihydroxy-4'-(4,4'-dimethoxytrityloxy)butyl]adenine (765912-07-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: pyridine / 20 °C

1.2: pyridine / 20 °C

2.1: aq. AcOH / 60 °C

3.1: 94 percent / pyridine / 20 °C

With pyridine; acetic acid;

DOI:10.1016/j.bmcl.2004.06.071

upstream raw materials:

4,4'-dimethoxytrityl chloride

N⁶-benzoyl-9-[(2'S,3'R)-2',3',4'-trihydroxybutyl]adenine

C₆H₅COC₅H₃N₅CH₂C₂H₂O₂C(CH₃)2CH₂OH

benzoyl chloride

Downstream raw materials:

N⁶-benzoyl-9-[(2'S,3'R)-3'-tert-butyldimethylsiloxy-2'-hydroxy-4'-(4,4'-dimethoxytrityloxy)butyl]adenine

N⁶-benzoyl-9-[(2'S,3'R)-2'-tert-butyldimethylsiloxy-3'-hydroxy-4'-(4,4'-dimethoxytrityloxy)butyl]adenine

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