(S)-diethyl 1-phenyl-3-oxo-3-pyrrol-1-yl-propylphosphonate

Base Information

• Chemical Name: (S)-diethyl 1-phenyl-3-oxo-3-pyrrol-1-yl-propylphosphonate
• CAS No.: 1201762-07-3
• Molecular Formula: C₁₇H₂₂NO₄P
• Molecular Weight: 335.34
• Mol file: 1201762-07-3.mol

Synonyms:(S)-diethyl 1-phenyl-3-oxo-3-pyrrol-1-yl-propylphosphonate

Chemical Property of (S)-diethyl 1-phenyl-3-oxo-3-pyrrol-1-yl-propylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of (S)-diethyl 1-phenyl-3-oxo-3-pyrrol-1-yl-propylphosphonate

There total 1 articles about (S)-diethyl 1-phenyl-3-oxo-3-pyrrol-1-yl-propylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

phosphonic acid diethyl ester (762-04-9) + 3-phenyl-1-pyrrol-1-yl-2-propen-1-one (949013-80-3) → (S)-diethyl 1-phenyl-3-oxo-3-pyrrol-1-yl-propylphosphonate (1201762-07-3)

Guidance literature:

With diethylzinc; ((2S,2'S)-((2-hydroxy-5-methyl-1,3-phenylene)bis(methylene))bis(pyrrolidine-1,2-diyl))bis(diphenylmethanol); In toluene; at 0 - 20 ℃; for 12h; optical yield given as %ee; enantioselective reaction; Inert atmosphere; Molecular sieve;

DOI:10.1002/chem.200901901

Reference yield: 93.0%

(S)-diethyl 1-phenyl-3-oxo-3-pyrrol-1-yl-propylphosphonate (1201762-07-3) → (S)-3-(diethoxyphosphoryl)-3-phenylpropanoic acid (1201762-36-8)

Guidance literature:

With water; sodium hydroxide; In methanol; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/chem.200901901

Reference yield: 91.0%

(S)-diethyl 1-phenyl-3-oxo-3-pyrrol-1-yl-propylphosphonate (1201762-07-3) + sodium methylate (124-41-4) → (S)-methyl 3-(diethoxyphosphoryl)-3-phenylpropanoate (1201762-31-3)

Guidance literature:

With methanol; In tetrahydrofuran; at 0 ℃; for 0.166667h; optical yield given as %ee; Inert atmosphere;

DOI:10.1002/chem.200901901

upstream raw materials:

phosphonic acid diethyl ester

3-phenyl-1-pyrrol-1-yl-2-propen-1-one

Downstream raw materials:

(S)-diethyl 3-oxo-1-phenyl-3-(piperidin-1-yl)propylphosphonate

(S)-3-(diethoxyphosphoryl)-3-phenylpropanoic acid

(S)-methyl 3-(diethoxyphosphoryl)-3-phenylpropanoate

C₂₀H₂₆NO₄P