3-(thiophen-2-ylthio)-1-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)propan-1-one

Base Information

Chemical Name:3-(thiophen-2-ylthio)-1-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)propan-1-one
CAS No.:1432445-18-5
Molecular Formula:C₁₈H₁₉F₃N₂OS₂
Molecular Weight:400.489
Hs Code.:

Synonyms:3-(thiophen-2-ylthio)-1-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)propan-1-one

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Chemical Property of 3-(thiophen-2-ylthio)-1-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)propan-1-one

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Technology Process of 3-(thiophen-2-ylthio)-1-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)propan-1-one

There total 3 articles about 3-(thiophen-2-ylthio)-1-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 7675-14-1
3-(thiophen-3-ylthio)propanoic acid

: 30459-17-7
1-[4-(trifluoromethyl)phenyl]piperazine

: 1432445-18-5
3-(thiophen-2-ylthio)-1-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)propan-1-one

Guidance literature:: 3-(thiophen-3-ylthio)propanoic acid; With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h; Inert atmosphere;

1-[4-(trifluoromethyl)phenyl]piperazine; In N,N-dimethyl-formamide; for 24h; Inert atmosphere;

Reference yield: 60.0%

: 7675-01-6
3-(thien-2-ylthio)propionic acid

: 30459-17-7
1-[4-(trifluoromethyl)phenyl]piperazine

: 1432445-18-5
3-(thiophen-2-ylthio)-1-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)propan-1-one

Guidance literature:: 3-(thien-2-ylthio)propionic acid; With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

1-[4-(trifluoromethyl)phenyl]piperazine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1016/j.ejmech.2020.112416

Reference yield:

: 98-56-6
4-chlorobenzotrifluoride

: 1432445-18-5
3-(thiophen-2-ylthio)-1-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)propan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-methyl-pyrrolidin-2-one / 0.5 h / 200 °C / Microwave irradiation

2.1: benzotriazol-1-ol; triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.25 h / 20 °C

2.2: 18 h / 20 °C

With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2020.112416