[11-(4-benzyloxy-2-fluoro-phenyl)-3,3-dimethyl-1,1-dioxo-1,2,3,4,5,11-hexahydro-1λ6-thia-5,10-diaza-dibenzo[a,d]cyclohepten-10-yl]-pyridin-2-yl-methanone

Base Information

Chemical Name:[11-(4-benzyloxy-2-fluoro-phenyl)-3,3-dimethyl-1,1-dioxo-1,2,3,4,5,11-hexahydro-1λ6-thia-5,10-diaza-dibenzo[a,d]cyclohepten-10-yl]-pyridin-2-yl-methanone
CAS No.:1049088-67-6
Molecular Formula:C₃₃H₃₀FN₃O₄S
Molecular Weight:583.683
Hs Code.:

[11-(4-benzyloxy-2-fluoro-phenyl)-3,3-dimethyl-1,1-dioxo-1,2,3,4,5,11-hexahydro-1λ6-thia-5,10-diaza-dibenzo[a,d]cyclohepten-10-yl]-pyridin-2-yl-methanone

Synonyms:[11-(4-benzyloxy-2-fluoro-phenyl)-3,3-dimethyl-1,1-dioxo-1,2,3,4,5,11-hexahydro-1λ6-thia-5,10-diaza-dibenzo[a,d]cyclohepten-10-yl]-pyridin-2-yl-methanone

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Chemical Property of [11-(4-benzyloxy-2-fluoro-phenyl)-3,3-dimethyl-1,1-dioxo-1,2,3,4,5,11-hexahydro-1λ6-thia-5,10-diaza-dibenzo[a,d]cyclohepten-10-yl]-pyridin-2-yl-methanone

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Technology Process of [11-(4-benzyloxy-2-fluoro-phenyl)-3,3-dimethyl-1,1-dioxo-1,2,3,4,5,11-hexahydro-1λ6-thia-5,10-diaza-dibenzo[a,d]cyclohepten-10-yl]-pyridin-2-yl-methanone

There total 7 articles about [11-(4-benzyloxy-2-fluoro-phenyl)-3,3-dimethyl-1,1-dioxo-1,2,3,4,5,11-hexahydro-1λ6-thia-5,10-diaza-dibenzo[a,d]cyclohepten-10-yl]-pyridin-2-yl-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 29745-44-6
pyridine-2-carbonyl chloride

: C₂₇H₂₇ClN₂O₃S

: 1049088-67-6
[11-(4-benzyloxy-2-fluoro-phenyl)-3,3-dimethyl-1,1-dioxo-1,2,3,4,5,11-hexahydro-1λ6-thia-5,10-diaza-dibenzo[a,d]cyclohepten-10-yl]-pyridin-2-yl-methanone

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

: 18615-62-8
5,5-dimethyl-dihydro-thiopyran-3-one

: 1049088-67-6
[11-(4-benzyloxy-2-fluoro-phenyl)-3,3-dimethyl-1,1-dioxo-1,2,3,4,5,11-hexahydro-1λ6-thia-5,10-diaza-dibenzo[a,d]cyclohepten-10-yl]-pyridin-2-yl-methanone

Guidance literature:: Multi-step reaction with 4 steps

1: 3-chloro-benzenecarboperoxoic acid / chloroform / 4 h

2: acetic acid / toluene / 15 h / 20 °C / Molecular sieve; Heating / reflux

3: toluene-4-sulfonic acid / dimethyl sulfoxide / 4 h / 75 °C

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C

With toluene-4-sulfonic acid; acetic acid; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; chloroform; dimethyl sulfoxide; toluene;

Reference yield:

: 504414-32-8
4-(benzyloxy)-2-fluorobenzaldehyde

: 1049088-67-6
[11-(4-benzyloxy-2-fluoro-phenyl)-3,3-dimethyl-1,1-dioxo-1,2,3,4,5,11-hexahydro-1λ6-thia-5,10-diaza-dibenzo[a,d]cyclohepten-10-yl]-pyridin-2-yl-methanone

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / dimethyl sulfoxide / 4 h / 75 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C

With toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In dichloromethane; dimethyl sulfoxide;