3''-N-acetyl-3,2',6'-tri-N-benzoyl-1-deamino-1-oxosisomicin

Base Information

• Chemical Name: 3''-N-acetyl-3,2',6'-tri-N-benzoyl-1-deamino-1-oxosisomicin
• CAS No.: 79249-24-4
• Molecular Formula: C₄₂H₄₈N₄O₁₂
• Molecular Weight: 800.863
• Mol file: 79249-24-4.mol

Synonyms:3''-N-acetyl-3,2',6'-tri-N-benzoyl-1-deamino-1-oxosisomicin

Chemical Property of 3''-N-acetyl-3,2',6'-tri-N-benzoyl-1-deamino-1-oxosisomicin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3''-N-acetyl-3,2',6'-tri-N-benzoyl-1-deamino-1-oxosisomicin

There total 2 articles about 3''-N-acetyl-3,2',6'-tri-N-benzoyl-1-deamino-1-oxosisomicin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3''-N-acetyl-3,2',6'-tri-N-benzoylsisomicin (79249-23-3) → 3''-N-acetyl-3,2',6'-tri-N-benzoyl-1-deamino-1-oxosisomicin (79249-24-4)

Guidance literature:

With malonic acid; 3,5-di-tert-butyl-o-benzoquinone; In tetrahydrofuran; methanol; at 25 ℃; for 42h; pH = 4;

DOI:10.1039/P19810002168

Reference yield:

3,2',6'-tri-N-benzoylsisomicin (79249-22-2) → 3''-N-acetyl-3,2',6'-tri-N-benzoyl-1-deamino-1-oxosisomicin (79249-24-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / tetrahydrofuran; H₂O / 16 h / 25 °C

2: 85 percent / 3,5-di-t-butyl-1,2-benzoquinone, aq. malonic acid / methanol; tetrahydrofuran / 42 h / 25 °C / pH = 4

With malonic acid; 3,5-di-tert-butyl-o-benzoquinone; In tetrahydrofuran; methanol; water;

DOI:10.1039/P19810002168

Reference yield:

3''-N-acetyl-3,2',6'-tri-N-benzoyl-1-deamino-1-oxosisomicin (79249-24-4) → C42H50N4O12

Guidance literature:

With L-Selectride; In tetrahydrofuran; at -78 ℃; for 2h;

DOI:10.1039/P19810002168

upstream raw materials:

3''-N-acetyl-3,2',6'-tri-N-benzoylsisomicin

3,2',6'-tri-N-benzoylsisomicin

Downstream raw materials:

1-deamino-1-hydroxysisomicin

1-deamino-1-epi-hydroxysisomicin

1-epi-N-ethylsisomicin