ETHYL 2-(1-ALLYL-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDEN)ACETATE

Base Information

• Chemical Name: ETHYL 2-(1-ALLYL-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDEN)ACETATE
• CAS No.: 1308732-57-1
• Molecular Formula: C₁₅H₁₅NO₃
• Molecular Weight: 257.289
• Hs Code.: 2933998090
• Mol file: 1308732-57-1.mol

Synonyms:(E)-ethyl 2-(1-allyl-2-oxoindoline-3-ylidene)acetate

Chemical Property of ETHYL 2-(1-ALLYL-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDEN)ACETATE

Chemical Property:

Purity/Quality:

Ethyl 2-(1-allyl-2-oxo-1,2-dihydro-3H-indol-3-yliden)acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ETHYL 2-(1-ALLYL-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDEN)ACETATE

There total 3 articles about ETHYL 2-(1-ALLYL-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDEN)ACETATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

1-allyl-1H-indole-2,3-dione (830-74-0) + ethyl (triphenylphosphoranylidene)acetate (1099-45-2) → (E)-ethyl 2-(1-allyl-2-oxoindoline-3-ylidene)acetate (1308732-57-1)

Guidance literature:

In toluene; at 20 ℃; for 8h;

DOI:10.1002/ejoc.201100017

Reference yield: 41.0%

glyoxylic acid ethyl ester (924-44-7) + C12H10N2O3 → (E)-ethyl 2-(1-allyl-2-oxoindoline-3-ylidene)acetate (1308732-57-1)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; In toluene; acetonitrile; at 20 ℃; for 0.75h; stereoselective reaction;

DOI:10.1002/ejoc.202000852

Reference yield:

indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) → (E)-ethyl 2-(1-allyl-2-oxoindoline-3-ylidene)acetate (1308732-57-1)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: toluene / 8 h / 20 °C

With potassium carbonate; In N,N-dimethyl-formamide; toluene;

DOI:10.1002/ejoc.201100017

upstream raw materials:

1-allyl-1H-indole-2,3-dione

ethyl (triphenylphosphoranylidene)acetate

indole-2,3-dione

glyoxylic acid ethyl ester

Downstream raw materials:

C₃₁H₂₇N₃O₄S