tert-Butyl 1-[(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)(cyclopropyloxy)methyl]cyclopropanecarboxylate

Base Information

Chemical Name:tert-Butyl 1-[(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)(cyclopropyloxy)methyl]cyclopropanecarboxylate
CAS No.:1380671-61-3
Molecular Formula:C₂₉H₃₂Cl₂F₃NO₄
Molecular Weight:586.479
Hs Code.:

tert-Butyl 1-[(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)(cyclopropyloxy)methyl]cyclopropanecarboxylate

Synonyms:tert-Butyl 1-[(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)(cyclopropyloxy)methyl]cyclopropanecarboxylate

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Chemical Property of tert-Butyl 1-[(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)(cyclopropyloxy)methyl]cyclopropanecarboxylate

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Technology Process of tert-Butyl 1-[(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)(cyclopropyloxy)methyl]cyclopropanecarboxylate

There total 7 articles about tert-Butyl 1-[(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)(cyclopropyloxy)methyl]cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 593-71-5
Chloroiodomethane

: 1380671-60-2
tert-Butyl 1-[(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)(vinyloxy)methyl]cyclopropanecarboxylate

: 1380671-61-3
tert-Butyl 1-[(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)(cyclopropyloxy)methyl]cyclopropanecarboxylate

Guidance literature:: With zinc/copper pair; In diethyl ether; Reflux;

Reference yield:

: 87661-20-9
tert-butyl cyclopropanecarboxylate

: 1380671-61-3
tert-Butyl 1-[(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)(cyclopropyloxy)methyl]cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 4 h / -78 °C

1.2: 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 72 h / 760.05 Torr

3.1: pyridine; HATU / N,N-dimethyl-formamide / 72 h / 20 °C

4.1: diacetato(1,10-phenantroline)palladium(II) / dichloromethane / 50 °C / Inert atmosphere

5.1: zinc/copper pair / diethyl ether / Reflux

With pyridine; n-butyllithium; hydrogen; diisopropylamine; HATU; palladium 10% on activated carbon; diacetato(1,10-phenantroline)palladium(II); In tetrahydrofuran; diethyl ether; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 16588-34-4
4-chloro-3-nitro-benzaldehyde

: 1380671-61-3
tert-Butyl 1-[(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)(cyclopropyloxy)methyl]cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 4 h / -78 °C

1.2: 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 72 h / 760.05 Torr

3.1: pyridine; HATU / N,N-dimethyl-formamide / 72 h / 20 °C

4.1: diacetato(1,10-phenantroline)palladium(II) / dichloromethane / 50 °C / Inert atmosphere

5.1: zinc/copper pair / diethyl ether / Reflux

With pyridine; n-butyllithium; hydrogen; diisopropylamine; HATU; palladium 10% on activated carbon; diacetato(1,10-phenantroline)palladium(II); In tetrahydrofuran; diethyl ether; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;