5α-3β,17β-bis[(((4',4'-bis(3''-methoxycarbonyl-5''-chloro-4''-methoxyphenyl)-3'-butenyl)amino)carbonyl)methyl]androstane

Base Information

Chemical Name:5α-3β,17β-bis[(((4',4'-bis(3''-methoxycarbonyl-5''-chloro-4''-methoxyphenyl)-3'-butenyl)amino)carbonyl)methyl]androstane
CAS No.:386210-66-8
Molecular Formula:C₆₇H₇₈Cl₄N₂O₁₄
Molecular Weight:1277.17
Hs Code.:

Synonyms:5α-3β,17β-bis[(((4',4'-bis(3''-methoxycarbonyl-5''-chloro-4''-methoxyphenyl)-3'-butenyl)amino)carbonyl)methyl]androstane

Suppliers and Price of 5α-3β,17β-bis[(((4',4'-bis(3''-methoxycarbonyl-5''-chloro-4''-methoxyphenyl)-3'-butenyl)amino)carbonyl)methyl]androstane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5α-3β,17β-bis[(((4',4'-bis(3''-methoxycarbonyl-5''-chloro-4''-methoxyphenyl)-3'-butenyl)amino)carbonyl)methyl]androstane

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 5α-3β,17β-bis[(((4',4'-bis(3''-methoxycarbonyl-5''-chloro-4''-methoxyphenyl)-3'-butenyl)amino)carbonyl)methyl]androstane

There total 7 articles about 5α-3β,17β-bis[(((4',4'-bis(3''-methoxycarbonyl-5''-chloro-4''-methoxyphenyl)-3'-butenyl)amino)carbonyl)methyl]androstane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5α-3,17-bis(cyanomethylidene)androstane

: 386210-66-8
5α-3β,17β-bis[(((4',4'-bis(3''-methoxycarbonyl-5''-chloro-4''-methoxyphenyl)-3'-butenyl)amino)carbonyl)methyl]androstane

Guidance literature:: Multi-step reaction with 6 steps

1: 65 percent / sodium hydroxide / ethane-1,2-diol; H₂O / 72 h / Heating

2: 65.6 percent / potassium carbonate / acetone / 24 h / Heating

3: 98 percent / hydrogen / 10 percent Pd/C / ethyl acetate / 48 h / 20 °C / atmospheric pressure

4: 86.2 percent / sodium hydroxide / tetrahydrofuran / 24 h / Heating

5: oxalyl chloride; N,N-dimethylformamide / tetrahydrofuran / 5 h / 20 °C

6: 112 mg / triethylamine / CH₂Cl₂ / 0 - 25 °C

With sodium hydroxide; oxalyl dichloride; hydrogen; potassium carbonate; triethylamine; N,N-dimethyl-formamide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; water; ethylene glycol; ethyl acetate; acetone;
DOI:10.1016/S0968-0896(01)00152-3

Reference yield:

: 386210-51-1
5α-3,17-bis(carboxymethylidene)androstane

: 386210-66-8
5α-3β,17β-bis[(((4',4'-bis(3''-methoxycarbonyl-5''-chloro-4''-methoxyphenyl)-3'-butenyl)amino)carbonyl)methyl]androstane

Guidance literature:: Multi-step reaction with 5 steps

1: 65.6 percent / potassium carbonate / acetone / 24 h / Heating

2: 98 percent / hydrogen / 10 percent Pd/C / ethyl acetate / 48 h / 20 °C / atmospheric pressure

3: 86.2 percent / sodium hydroxide / tetrahydrofuran / 24 h / Heating

4: oxalyl chloride; N,N-dimethylformamide / tetrahydrofuran / 5 h / 20 °C

5: 112 mg / triethylamine / CH₂Cl₂ / 0 - 25 °C

With sodium hydroxide; oxalyl dichloride; hydrogen; potassium carbonate; triethylamine; N,N-dimethyl-formamide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; acetone;
DOI:10.1016/S0968-0896(01)00152-3

Reference yield:

: 386210-52-2
5α-3,17-bis(methoxycarbonylmethylidene)androstane

: 386210-66-8
5α-3β,17β-bis[(((4',4'-bis(3''-methoxycarbonyl-5''-chloro-4''-methoxyphenyl)-3'-butenyl)amino)carbonyl)methyl]androstane

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / hydrogen / 10 percent Pd/C / ethyl acetate / 48 h / 20 °C / atmospheric pressure

2: 86.2 percent / sodium hydroxide / tetrahydrofuran / 24 h / Heating

3: oxalyl chloride; N,N-dimethylformamide / tetrahydrofuran / 5 h / 20 °C

4: 112 mg / triethylamine / CH₂Cl₂ / 0 - 25 °C

With sodium hydroxide; oxalyl dichloride; hydrogen; triethylamine; N,N-dimethyl-formamide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1016/S0968-0896(01)00152-3