[5-(tert-Butyl-dimethyl-silanyloxy)-5-((Z)-6-iodo-hex-3-ene-1,5-diynyl)-2-methyl-cyclohex-1-enyl]-methanol

Base Information

Chemical Name:[5-(tert-Butyl-dimethyl-silanyloxy)-5-((Z)-6-iodo-hex-3-ene-1,5-diynyl)-2-methyl-cyclohex-1-enyl]-methanol
CAS No.:213924-93-7
Molecular Formula:C₂₀H₂₉IO₂Si
Molecular Weight:456.439
Hs Code.:

Synonyms:[5-(tert-Butyl-dimethyl-silanyloxy)-5-((Z)-6-iodo-hex-3-ene-1,5-diynyl)-2-methyl-cyclohex-1-enyl]-methanol

Suppliers and Price of [5-(tert-Butyl-dimethyl-silanyloxy)-5-((Z)-6-iodo-hex-3-ene-1,5-diynyl)-2-methyl-cyclohex-1-enyl]-methanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of [5-(tert-Butyl-dimethyl-silanyloxy)-5-((Z)-6-iodo-hex-3-ene-1,5-diynyl)-2-methyl-cyclohex-1-enyl]-methanol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [5-(tert-Butyl-dimethyl-silanyloxy)-5-((Z)-6-iodo-hex-3-ene-1,5-diynyl)-2-methyl-cyclohex-1-enyl]-methanol

There total 9 articles about [5-(tert-Butyl-dimethyl-silanyloxy)-5-((Z)-6-iodo-hex-3-ene-1,5-diynyl)-2-methyl-cyclohex-1-enyl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 213924-92-6
[5-(tert-Butyl-dimethyl-silanyloxy)-5-((Z)-hex-3-ene-1,5-diynyl)-2-methyl-cyclohex-1-enyl]-methanol

: 213924-93-7
[5-(tert-Butyl-dimethyl-silanyloxy)-5-((Z)-6-iodo-hex-3-ene-1,5-diynyl)-2-methyl-cyclohex-1-enyl]-methanol

Guidance literature:: With morpholine; iodine; In benzene; at 60 ℃; for 2h;
DOI:10.1016/S0040-4039(98)01297-0

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 213924-93-7
[5-(tert-Butyl-dimethyl-silanyloxy)-5-((Z)-6-iodo-hex-3-ene-1,5-diynyl)-2-methyl-cyclohex-1-enyl]-methanol

Guidance literature:: Multi-step reaction with 9 steps

1: 60 percent / LDA, HMPA / tetrahydrofuran / 0.5 h / -78 °C

2: 99 percent / KHMDS / tetrahydrofuran / 1 h / -78 - 21 °C

3: 99 percent / diethyl ether / -78 - 21 °C

4: 80 percent / 35percent aq. CF₃COOH / CHCl₃ / 72 h / 21 °C

5: 84 percent / t-BuLi, CeCl₃ / tetrahydrofuran / 0.17 h / -78 °C

6: 98 percent / Et₃N / CH₂Cl₂ / 0 - 21 °C

7: 99 percent / i-Bu₂AlH / CH₂Cl₂ / 2 h / -78 - -60 °C

8: 93 percent / n-Bu₄NF / tetrahydrofuran / 4 h / -78 - 0 °C

9: 69 percent / I₂, morpholine / benzene / 2 h / 60 °C

With morpholine; N,N,N,N,N,N-hexamethylphosphoric triamide; cerium(III) chloride; tetrabutyl ammonium fluoride; iodine; tert.-butyl lithium; potassium hexamethylsilazane; diisobutylaluminium hydride; triethylamine; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; dichloromethane; chloroform; benzene;
DOI:10.1016/S0040-4039(98)01297-0

Reference yield:

: 14160-65-7,77793-24-9,122090-88-4
ethyl 8-oxo-1,4-dioxaspiro[4.5]decane-7-carboxylate

: 213924-93-7
[5-(tert-Butyl-dimethyl-silanyloxy)-5-((Z)-6-iodo-hex-3-ene-1,5-diynyl)-2-methyl-cyclohex-1-enyl]-methanol

Guidance literature:: Multi-step reaction with 8 steps

1: 99 percent / KHMDS / tetrahydrofuran / 1 h / -78 - 21 °C

2: 99 percent / diethyl ether / -78 - 21 °C

3: 80 percent / 35percent aq. CF₃COOH / CHCl₃ / 72 h / 21 °C

4: 84 percent / t-BuLi, CeCl₃ / tetrahydrofuran / 0.17 h / -78 °C

5: 98 percent / Et₃N / CH₂Cl₂ / 0 - 21 °C

6: 99 percent / i-Bu₂AlH / CH₂Cl₂ / 2 h / -78 - -60 °C

7: 93 percent / n-Bu₄NF / tetrahydrofuran / 4 h / -78 - 0 °C

8: 69 percent / I₂, morpholine / benzene / 2 h / 60 °C

With morpholine; cerium(III) chloride; tetrabutyl ammonium fluoride; iodine; tert.-butyl lithium; potassium hexamethylsilazane; diisobutylaluminium hydride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; dichloromethane; chloroform; benzene;
DOI:10.1016/S0040-4039(98)01297-0