(3aS,8aR)-3a,8-dibenzyl-1-methyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole

Base Information

Chemical Name:(3aS,8aR)-3a,8-dibenzyl-1-methyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole
CAS No.:799561-41-4
Molecular Formula:C₂₅H₂₆N₂
Molecular Weight:354.495
Hs Code.:

Synonyms:(3aS,8aR)-3a,8-dibenzyl-1-methyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole

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Chemical Property of (3aS,8aR)-3a,8-dibenzyl-1-methyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole

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Technology Process of (3aS,8aR)-3a,8-dibenzyl-1-methyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole

There total 2 articles about (3aS,8aR)-3a,8-dibenzyl-1-methyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 593-51-1
methylamine hydrochloride

: 799561-33-4
(S)-(1,3-dibenzyl-2-oxo-2,3-dihydro-1H-indol-3-yl)acetaldehyde

: 799561-41-4
(3aS,8aR)-3a,8-dibenzyl-1-methyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole

Guidance literature:: methylamine hydrochloride; (S)-(1,3-dibenzyl-2-oxo-2,3-dihydro-1H-indol-3-yl)acetaldehyde; With magnesium sulfate; triethylamine; In tetrahydrofuran; at 20 ℃; for 48h;

With lithium aluminium tetrahydride; In tetrahydrofuran; for 1.5h; Heating;
DOI:10.1021/ja046690e

Reference yield:

: 799561-67-4
C₄₈H₄₄N₂O₄

: 799561-41-4
(3aS,8aR)-3a,8-dibenzyl-1-methyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole

Guidance literature:: Multi-step reaction with 2 steps

1.1: aq. NaIO₄ / tetrahydrofuran / 18 h / 20 °C

2.1: Et₃N; MgSO₄ / tetrahydrofuran / 48 h / 20 °C

2.2: 58 percent / LiAlH₄ / tetrahydrofuran / 1.5 h / Heating

With sodium periodate; magnesium sulfate; triethylamine; In tetrahydrofuran;
DOI:10.1021/ja046690e