2-(2-chlorobenzyl)-4-{[2-methoxy-4-(piperazin-1-ylmethyl)phenyl]amino}pyrido[2,3-d]pyridazin-5(6H)-one

Base Information

Chemical Name:2-(2-chlorobenzyl)-4-{[2-methoxy-4-(piperazin-1-ylmethyl)phenyl]amino}pyrido[2,3-d]pyridazin-5(6H)-one
CAS No.:1390656-12-8
Molecular Formula:C₂₆H₂₇ClN₆O₂
Molecular Weight:490.992
Hs Code.:

Synonyms:2-(2-chlorobenzyl)-4-{[2-methoxy-4-(piperazin-1-ylmethyl)phenyl]amino}pyrido[2,3-d]pyridazin-5(6H)-one

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Chemical Property of 2-(2-chlorobenzyl)-4-{[2-methoxy-4-(piperazin-1-ylmethyl)phenyl]amino}pyrido[2,3-d]pyridazin-5(6H)-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-(2-chlorobenzyl)-4-{[2-methoxy-4-(piperazin-1-ylmethyl)phenyl]amino}pyrido[2,3-d]pyridazin-5(6H)-one

There total 8 articles about 2-(2-chlorobenzyl)-4-{[2-methoxy-4-(piperazin-1-ylmethyl)phenyl]amino}pyrido[2,3-d]pyridazin-5(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1390657-78-9
tert-butyl 4-(4-((2-(2-chlorobenzyl)-5-oxo-5,6-dihydropyrido[2,3-d]pyridazin-4-yl)amino)-3-methoxybenzyl)piperazine-1-carboxylate

: 1390656-12-8
2-(2-chlorobenzyl)-4-{[2-methoxy-4-(piperazin-1-ylmethyl)phenyl]amino}pyrido[2,3-d]pyridazin-5(6H)-one

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 686279-09-4
ethyl 4,6-dichloro-2-methylpyridine-3-carboxylate

: 1390656-12-8
2-(2-chlorobenzyl)-4-{[2-methoxy-4-(piperazin-1-ylmethyl)phenyl]amino}pyrido[2,3-d]pyridazin-5(6H)-one

Guidance literature:: Multi-step reaction with 7 steps

1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 24 h / 85 °C

2: N-methylpiperidine-N-oxide / acetonitrile / 1 h / 20 °C / Molecular sieve

3: 1,4-dioxane / 15 h / 20 °C

4: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 24 h / 120 °C / Sealed tube

6: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 15 h / 72 °C / Inert atmosphere

7: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With N-methylpiperidine-N-oxide; N-Bromosuccinimide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; dibenzoyl peroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; dichloromethane; acetonitrile;

Reference yield:

: 3950-10-5,70254-48-7,70254-49-8
4,6-dihydroxy-2-methyl nicotinic acid ethyl ester

: 1390656-12-8
2-(2-chlorobenzyl)-4-{[2-methoxy-4-(piperazin-1-ylmethyl)phenyl]amino}pyrido[2,3-d]pyridazin-5(6H)-one

Guidance literature:: Multi-step reaction with 8 steps

1: trichlorophosphate / 2.5 h / 140 °C

2: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 24 h / 85 °C

3: N-methylpiperidine-N-oxide / acetonitrile / 1 h / 20 °C / Molecular sieve

4: 1,4-dioxane / 15 h / 20 °C

5: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

6: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 24 h / 120 °C / Sealed tube

7: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 15 h / 72 °C / Inert atmosphere

8: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With N-methylpiperidine-N-oxide; N-Bromosuccinimide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; trichlorophosphate; dibenzoyl peroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; dichloromethane; acetonitrile;