(R)-[[3-[3-fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]isothiocyanate

Base Information

• Chemical Name: (R)-[[3-[3-fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]isothiocyanate
• CAS No.: 221201-58-7
• Molecular Formula: C₁₅H₁₆FN₃O₂S₂
• Molecular Weight: 353.441
• Mol file: 221201-58-7.mol

Synonyms:(R)-[[3-[3-fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]isothiocyanate

Chemical Property of (R)-[[3-[3-fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]isothiocyanate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-[[3-[3-fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]isothiocyanate

There total 1 articles about (R)-[[3-[3-fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]isothiocyanate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

carbon disulfide (75-15-0,12122-00-8) + (5S)-5-(aminomethyl)-3-(3-fluoro-4-thiomorpholin-4-ylphenyl)-1,3-oxazolidin-2-one (216869-36-2) → (R)-[[3-[3-fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]isothiocyanate (221201-58-7)

Guidance literature:

carbon disulfide; (5S)-5-(aminomethyl)-3-(3-fluoro-4-thiomorpholin-4-ylphenyl)-1,3-oxazolidin-2-one; With triethylamine; In tetrahydrofuran; at 20 ℃; for 5h;

With chloroformic acid ethyl ester; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1248/cpb.49.347

Reference yield: 78.0%

ethanol (64-17-5) + (R)-[[3-[3-fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]isothiocyanate (221201-58-7) → (S)-N-[[3-[3-fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-O-ethylthiocarbamate

Guidance literature:

With sodium hydride; at 20 ℃; for 3h;

DOI:10.1248/cpb.49.361

Reference yield: 42.0%

(R)-[[3-[3-fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]isothiocyanate (221201-58-7) → (S)-N-[[3-[3-Fluoro4-(4-thiomorpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]thiourea

Guidance literature:

With ammonia; In methanol; at 20 ℃; for 2h;

DOI:10.1248/cpb.49.347

upstream raw materials:

carbon disulfide

(5S)-5-(aminomethyl)-3-(3-fluoro-4-thiomorpholin-4-ylphenyl)-1,3-oxazolidin-2-one