1-(2'-Chloroacetylaminophenyl)-4,4-dimethyl-1,4-dihydro-3(2H)-isoquinolinone

Base Information

• Chemical Name: 1-(2'-Chloroacetylaminophenyl)-4,4-dimethyl-1,4-dihydro-3(2H)-isoquinolinone
• CAS No.: 93214-08-5
• Molecular Formula: C₁₉H₁₉ClN₂O₂
• Molecular Weight: 342.825
• Mol file: 93214-08-5.mol

Synonyms:1-(2'-Chloroacetylaminophenyl)-4,4-dimethyl-1,4-dihydro-3(2H)-isoquinolinone

Chemical Property of 1-(2'-Chloroacetylaminophenyl)-4,4-dimethyl-1,4-dihydro-3(2H)-isoquinolinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2'-Chloroacetylaminophenyl)-4,4-dimethyl-1,4-dihydro-3(2H)-isoquinolinone

There total 4 articles about 1-(2'-Chloroacetylaminophenyl)-4,4-dimethyl-1,4-dihydro-3(2H)-isoquinolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-(2'-Aminophenyl)-4,4-dimethyl-1,4-dihydro-3(2H)-isoquinolinone (64097-19-4) + chloroacetyl chloride (79-04-9) → 1-(2'-Chloroacetylaminophenyl)-4,4-dimethyl-1,4-dihydro-3(2H)-isoquinolinone (93214-08-5)

Guidance literature:

With triethylamine; In acetic acid; at 50 - 55 ℃; for 6h;

DOI:10.1002/jhet.5570210424

Reference yield:

4,4-Dimethyl-1-(2'-nitrophenyl)-1,4-dihydro-3(2H)-isoquinolinone (56946-77-1) → 1-(2'-Chloroacetylaminophenyl)-4,4-dimethyl-1,4-dihydro-3(2H)-isoquinolinone (93214-08-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / Hydrogen / Pd/C / acetic acid / 0.33 h / 15001.2 - 18751.5 Torr / Ambient temperature

2: 90 percent / Triethylamine / acetic acid / 6 h / 50 - 55 °C

With hydrogen; triethylamine; palladium on activated charcoal; In acetic acid;

DOI:10.1002/jhet.5570210424

Reference yield:

(±)-3-methyl-2-phenylbutyramide (5470-47-3) → 1-(2'-Chloroacetylaminophenyl)-4,4-dimethyl-1,4-dihydro-3(2H)-isoquinolinone (93214-08-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) Polyphosphoric acid / 5 h / 77 - 80 °C

2: 92 percent / Hydrogen / Pd/C / acetic acid / 0.33 h / 15001.2 - 18751.5 Torr / Ambient temperature

3: 90 percent / Triethylamine / acetic acid / 6 h / 50 - 55 °C

With PPA; hydrogen; triethylamine; palladium on activated charcoal; In acetic acid;

DOI:10.1002/jhet.5570210424

upstream raw materials:

1-(2'-Aminophenyl)-4,4-dimethyl-1,4-dihydro-3(2H)-isoquinolinone

chloroacetyl chloride

4,4-Dimethyl-1-(2'-nitrophenyl)-1,4-dihydro-3(2H)-isoquinolinone

(±)-3-methyl-2-phenylbutyramide