3-[(2S,3R,4R)-4-(tert-Butyl-diphenyl-silanyloxy)-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-tetrahydro-furan-3-yl]-propionitrile

Base Information

Chemical Name:3-[(2S,3R,4R)-4-(tert-Butyl-diphenyl-silanyloxy)-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-tetrahydro-furan-3-yl]-propionitrile
CAS No.:385841-99-6
Molecular Formula:C₂₈H₃₇NO₄Si
Molecular Weight:479.692
Hs Code.:

Synonyms:3-[(2S,3R,4R)-4-(tert-Butyl-diphenyl-silanyloxy)-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-tetrahydro-furan-3-yl]-propionitrile

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Chemical Property of 3-[(2S,3R,4R)-4-(tert-Butyl-diphenyl-silanyloxy)-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-tetrahydro-furan-3-yl]-propionitrile

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Technology Process of 3-[(2S,3R,4R)-4-(tert-Butyl-diphenyl-silanyloxy)-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-tetrahydro-furan-3-yl]-propionitrile

There total 3 articles about 3-[(2S,3R,4R)-4-(tert-Butyl-diphenyl-silanyloxy)-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-tetrahydro-furan-3-yl]-propionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 143-33-9,25596-52-5
sodium cyanide

: 385841-98-5
Methanesulfonic acid 2-[(2S,3R,4R)-4-(tert-butyl-diphenyl-silanyloxy)-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-tetrahydro-furan-3-yl]-ethyl ester

: 385841-99-6
3-[(2S,3R,4R)-4-(tert-Butyl-diphenyl-silanyloxy)-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-tetrahydro-furan-3-yl]-propionitrile

Guidance literature:: In dimethyl sulfoxide; at 45 ℃;
DOI:10.1016/j.bmcl.2004.06.037

Reference yield:

: 385841-97-4
2-[(2S,3R,4R)-4-(tert-Butyl-diphenyl-silanyloxy)-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-tetrahydro-furan-3-yl]-ethanol

: 385841-99-6
3-[(2S,3R,4R)-4-(tert-Butyl-diphenyl-silanyloxy)-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-tetrahydro-furan-3-yl]-propionitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / Et₃N / CH₂Cl₂ / 0 °C

2: 95 percent / dimethylsulfoxide / 45 °C

With triethylamine; In dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2004.06.037

Reference yield:

: [(2S,3R,4R)-4-(tert-Butyl-diphenyl-silanyloxy)-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-tetrahydro-furan-3-yl]-acetic acid ethyl ester

: 385841-99-6
3-[(2S,3R,4R)-4-(tert-Butyl-diphenyl-silanyloxy)-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-tetrahydro-furan-3-yl]-propionitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / LiAlH₄ / diethyl ether / 0 °C

2: 98 percent / Et₃N / CH₂Cl₂ / 0 °C

3: 95 percent / dimethylsulfoxide / 45 °C

With lithium aluminium tetrahydride; triethylamine; In diethyl ether; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2004.06.037