1-[(6-chloro-2-naphthyl)sulfonyl]-4-[3-methoxy-4-(4-pyridyl)benzoyl]piperazine

Base Information

Chemical Name:1-[(6-chloro-2-naphthyl)sulfonyl]-4-[3-methoxy-4-(4-pyridyl)benzoyl]piperazine
CAS No.:792172-61-3
Molecular Formula:C₂₇H₂₄ClN₃O₄S
Molecular Weight:522.024
Hs Code.:

Synonyms:1-[(6-chloro-2-naphthyl)sulfonyl]-4-[3-methoxy-4-(4-pyridyl)benzoyl]piperazine

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Chemical Property of 1-[(6-chloro-2-naphthyl)sulfonyl]-4-[3-methoxy-4-(4-pyridyl)benzoyl]piperazine

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Technology Process of 1-[(6-chloro-2-naphthyl)sulfonyl]-4-[3-methoxy-4-(4-pyridyl)benzoyl]piperazine

There total 8 articles about 1-[(6-chloro-2-naphthyl)sulfonyl]-4-[3-methoxy-4-(4-pyridyl)benzoyl]piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 792172-61-3
1-[(6-chloro-2-naphthyl)sulfonyl]-4-[3-methoxy-4-(4-pyridyl)benzoyl]piperazine

: 1-[(6-chloro-2-naphthyl)sulfonyl]-4-[3-hydroxy-4-(4-pyridyl)benzoyl]piperazine hydrochloride

Guidance literature:

Reference yield:

: 17100-63-9
methyl 4-bromo-3-methoxybenzoate

: 792172-61-3
1-[(6-chloro-2-naphthyl)sulfonyl]-4-[3-methoxy-4-(4-pyridyl)benzoyl]piperazine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 92 percent / tetrabutylammonium bromide; potassium hydroxide / tetrakis(triphenylphosphine)palladium⁽⁰⁾ / tetrahydrofuran; H₂O / 2.5 h / Heating

2.1: 253 mg / HCl / H₂O / 5.5 h / Heating

3.1: HCl / ethanol / 0.05 h

3.2: 4-(N,N-dimethylamino)pyridine; ethyldiisopropylamine / CH₂Cl₂; dimethylformamide / 42 h / 20 °C

With hydrogenchloride; potassium hydroxide; tetrabutylammomium bromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; water; 1.1: Suzuki-Miyahara coupling;
DOI:10.1016/j.bmc.2005.04.006

Reference yield:

: 93830-58-1
diethyl (pyridin-4-yl)borane

: 792172-61-3
1-[(6-chloro-2-naphthyl)sulfonyl]-4-[3-methoxy-4-(4-pyridyl)benzoyl]piperazine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 92 percent / tetrabutylammonium bromide; potassium hydroxide / tetrakis(triphenylphosphine)palladium⁽⁰⁾ / tetrahydrofuran; H₂O / 2.5 h / Heating

2.1: 253 mg / HCl / H₂O / 5.5 h / Heating

3.1: HCl / ethanol / 0.05 h

3.2: 4-(N,N-dimethylamino)pyridine; ethyldiisopropylamine / CH₂Cl₂; dimethylformamide / 42 h / 20 °C

With hydrogenchloride; potassium hydroxide; tetrabutylammomium bromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; water; 1.1: Suzuki-Miyahara coupling;
DOI:10.1016/j.bmc.2005.04.006