methyl (2S)-2-acetamido-3-[2-(4-methoxyphenyl)-1H-indol-3-yl]propanoate

Base Information

• Chemical Name: methyl (2S)-2-acetamido-3-[2-(4-methoxyphenyl)-1H-indol-3-yl]propanoate
• CAS No.: 1217265-48-9
• Molecular Formula: C₂₁H₂₂N₂O₄
• Molecular Weight: 366.417
• Mol file: 1217265-48-9.mol

Synonyms:methyl (2S)-2-acetamido-3-[2-(4-methoxyphenyl)-1H-indol-3-yl]propanoate

Chemical Property of methyl (2S)-2-acetamido-3-[2-(4-methoxyphenyl)-1H-indol-3-yl]propanoate

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of methyl (2S)-2-acetamido-3-[2-(4-methoxyphenyl)-1H-indol-3-yl]propanoate

There total 4 articles about methyl (2S)-2-acetamido-3-[2-(4-methoxyphenyl)-1H-indol-3-yl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-methoxybenzenediazonium tetrafluoroborate (459-64-3) + N-acetyl-L-tryptophan methyl ester (2824-57-9,16108-06-8,36060-94-3) → methyl (2S)-2-acetamido-3-[2-(4-methoxyphenyl)-1H-indol-3-yl]propanoate (1217265-48-9)

Guidance literature:

With palladium diacetate; In ethyl acetate; at 0.2 ℃; for 24h; regioselective reaction;

DOI:10.1021/acscatal.6b03121

Reference yield: 76.0%

para-iodoanisole (696-62-8) + N-acetyl-L-tryptophan methyl ester (2824-57-9,16108-06-8,36060-94-3) → methyl (2S)-2-acetamido-3-[2-(4-methoxyphenyl)-1H-indol-3-yl]propanoate (1217265-48-9)

Guidance literature:

With silver tetrafluoroborate; ortho-nitrobenzoic acid; palladium diacetate; In N,N-dimethyl-formamide; at 20 - 150 ℃; for 0.583333h; chemoselective reaction; Microwave irradiation;

DOI:10.1002/chem.200902676

Reference yield: 28.0%

4-methoxyphenylboronic acid (5720-07-0) + methyl (2S)-3-(1H-indol-3-yl)-2-(trifluoroacetamido)propanoate (1604-49-5) → methyl (2S)-2-acetamido-3-[2-(4-methoxyphenyl)-1H-indol-3-yl]propanoate (1217265-48-9)

Guidance literature:

With copper diacetate; palladium diacetate; acetic acid; at 40 ℃; for 16h;

DOI:10.1039/c5ob01174d

upstream raw materials:

para-iodoanisole

N-acetyl-L-tryptophan methyl ester

4-methoxyphenylboronic acid

methyl (2S)-3-(1H-indol-3-yl)-2-(trifluoroacetamido)propanoate