(S)-10-(2-tert-butoxy-2-oxoethyl)-1-(9H-fluoren-9-yl)-14,14-dimethyl-3,12-dioxo-2,13-dioxa-4,10-diaza pentadecane-5-carboxylic acid

Base Information

Chemical Name:(S)-10-(2-tert-butoxy-2-oxoethyl)-1-(9H-fluoren-9-yl)-14,14-dimethyl-3,12-dioxo-2,13-dioxa-4,10-diaza pentadecane-5-carboxylic acid
CAS No.:151132-81-9
Molecular Formula:C₃₃H₄₄N₂O₈
Molecular Weight:596.721
Hs Code.:

Synonyms:(S)-10-(2-tert-butoxy-2-oxoethyl)-1-(9H-fluoren-9-yl)-14,14-dimethyl-3,12-dioxo-2,13-dioxa-4,10-diaza pentadecane-5-carboxylic acid

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Chemical Property of (S)-10-(2-tert-butoxy-2-oxoethyl)-1-(9H-fluoren-9-yl)-14,14-dimethyl-3,12-dioxo-2,13-dioxa-4,10-diaza pentadecane-5-carboxylic acid

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Technology Process of (S)-10-(2-tert-butoxy-2-oxoethyl)-1-(9H-fluoren-9-yl)-14,14-dimethyl-3,12-dioxo-2,13-dioxa-4,10-diaza pentadecane-5-carboxylic acid

There total 2 articles about (S)-10-(2-tert-butoxy-2-oxoethyl)-1-(9H-fluoren-9-yl)-14,14-dimethyl-3,12-dioxo-2,13-dioxa-4,10-diaza pentadecane-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 7633-32-1
tert-butyl glyoxylate

: 105047-45-8
Fmoc-Lys-OH

: 151132-81-9
(S)-10-(2-tert-butoxy-2-oxoethyl)-1-(9H-fluoren-9-yl)-14,14-dimethyl-3,12-dioxo-2,13-dioxa-4,10-diaza pentadecane-5-carboxylic acid

Guidance literature:: With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 0.5h;
DOI:10.1055/s-2004-829120

Reference yield:

: 7633-32-1
tert-butyl glyoxylate

: 151132-81-9
(S)-10-(2-tert-butoxy-2-oxoethyl)-1-(9H-fluoren-9-yl)-14,14-dimethyl-3,12-dioxo-2,13-dioxa-4,10-diaza pentadecane-5-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 0.5 h / 75 °C / Inert atmosphere

2: sodium tris(acetoxy)borohydride / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

With sodium tris(acetoxy)borohydride; In dichloromethane;
DOI:10.1021/bc900517x

Reference yield:

: C₆₆H₉₉N₉O₂₀PPol

: 151132-81-9
(S)-10-(2-tert-butoxy-2-oxoethyl)-1-(9H-fluoren-9-yl)-14,14-dimethyl-3,12-dioxo-2,13-dioxa-4,10-diaza pentadecane-5-carboxylic acid

: C₉₉H₁₄₁N₁₁O₂₇PPol

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; solid phase reaction;
DOI:10.1016/j.bioorg.2009.05.003