C₁₀H₈ClNO₃

Base Information

• Chemical Name: C₁₀H₈ClNO₃
• CAS No.: 855300-90-2
• Molecular Formula: C₁₀H₈ClNO₃
• Molecular Weight: 225.631
• Mol file: 855300-90-2.mol

Synonyms:C₁₀H₈ClNO₃

Chemical Property of C₁₀H₈ClNO₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of C₁₀H₈ClNO₃

There total 2 articles about C₁₀H₈ClNO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.8%

sodium diformamide (18197-26-7) + 2-chlorophenacyl bromide (5000-66-8) → C10H8ClNO3 (855300-90-2)

Guidance literature:

In acetonitrile; at 70 ℃; for 3h;

Reference yield:

1-(2-chlorophenyl)ethanone (2142-68-9) → C10H8ClNO3 (855300-90-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 40 percent / Br₂; AlCl₃ / diethyl ether / 8 h / 0 °C

2: 65 percent / acetonitrile / 2 h / 25 - 70 °C

With aluminium trichloride; bromine; In diethyl ether; acetonitrile;

DOI:10.1016/j.bmcl.2005.03.066

Reference yield: 96.0%

C10H8ClNO3 (855300-90-2) → 2-amino-1-(2-chlorophenyl)ethan-1-one hydrochloride (16442-79-8)

Guidance literature:

With hydrogenchloride; water; at 120 ℃; for 1h;

upstream raw materials:

sodium diformamide

2-chlorophenacyl bromide

1-(2-chlorophenyl)ethanone

Downstream raw materials:

N-[2-(2-chloro-phenyl)-2-oxo-ethyl]-oxalamic acid ethyl ester

(Z)-2-Benzoylamino-3-[5-(2-chloro-phenyl)-thiazol-2-yl]-acrylic acid methyl ester

5-(2-chloro-phenyl)-thiazole-2-carbaldehyde

[5-(2-chloro-phenyl)-thiazol-2-yl]-methanol

Refernces

• 1、 Pfefferkorn, Jeffrey A.,Greene, Meredith L.,Nugent, Richard A.,Gross, Rebecca J.,Mitchell, Mark A.,Finzel, Barry C.,Harris, Melissa S.,Wells, Peter A.,Shelly, John A.,Anstadt, Robert A.,Kilkuskie, Robert E.,Kopta, Laurice A.,Schwende, Francis J.. "Inhibitors of HCV NS5B polymerase. Part 1: Evaluation of the southern region of (2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid". . p. 2481 - 2486. Retrieved 2007/10/03.