16442-79-8

Usage

Uses

Used in Pharmaceutical Industry:
2-amino-1-(2-chlorophenyl)ethan-1-one hydrochloride is used as a precursor in the synthesis of other drugs and research compounds. Its versatile chemical reactivity allows for the creation of a wide range of pharmaceuticals, contributing to the development of new treatments and medications.
Used in Research Settings:
In research settings, 2-amino-1-(2-chlorophenyl)ethan-1-one hydrochloride is utilized for its potential biological effects. It serves as a valuable tool for studying various biological processes and mechanisms, aiding in the advancement of scientific understanding.
Used as a Reference Compound:
2-amino-1-(2-chlorophenyl)ethan-1-one hydrochloride is also used as a reference compound in analytical purposes. Its well-defined chemical structure and properties make it suitable for calibration and quality control in various analytical techniques, ensuring accurate and reliable results in chemical analyses.

InChI:InChI=1/C8H8ClNO.ClH/c9-7-4-2-1-3-6(7)8(11)5-10;/h1-4H,5,10H2;1H

Upstream product

• 855300-90-2 C₁₀H₈ClNO₃ 
• 5000-66-8 2-chlorophenacyl bromide 
• 93102-90-0 2-Amino-3-(2-chloro-phenyl)-3-oxo-propionic acid methyl ester; hydrochloride 
• 89204-91-1 5-(2-Chloro-phenyl)-oxazole-4-carboxylic acid methyl ester 

Downstream Products

• 23496-56-2 (+/-)-2-amino-1-(2-chlorophenyl)ethanol 
• 16442-80-1 2-amino-N-[2-(2-chlorophenyl)-2-oxoethyl]benzamide 
• 93103-16-3 4-(2-Chloro-phenyl)-1H-imidazole-2-thiol 

Relevant academic research and scientific papers

Preparation method of stable isotope-labeled clorprenaline

The invention relates to a preparation method of stable isotope-labeled clorprenaline. The preparation method comprises the following steps: with 2-bromo-2'-chloroacetophenone as an initial raw material, successively conducting improved Gabriel synthesis (wherein the initial raw material and an amination reagent sodium, namely diformyl amide are subjected to a nucleophilic substitution reaction), hydrolysis, reduction and reductive amination so as to synthesize the isotope-labeled clorprenaline . According to the preparation method disclosed by the invention, through a four-step conventional chemical reaction, process design is reasonable, raw material price is low, an experimental process is controllable, operation is simple and convenient, various required labeled compounds such as D-labeled, 13C-labeled or D/13C double-labeled compounds can be conveniently synthesized, the purity of the prepared target product is high and reaches 98% or above, total yield reaches 66% or above, the isotope abundance of the final product can reach 98% or above, the phenomenon of isotope abundance dilution is avoided, higher reproducibility and stability are achieved, and the obtained target compound can provide a standard reagent for accurately and quantitatively detecting trace residues of clorprenaline.

NADPH OXIDASE INHIBITORS, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND APPLICATION THEREOF

The present disclosure relates to a compound of Formula I, or a geometric isomer, enantiomer, diastereomer, racemate, atropisomer, pharmaceutically acceptable salt, prodrug or solvate thereof. The present disclosure further relates to a composition comprising the compound of Formula (I). The compound and the composition described herein can be used to inhibit NADPH oxidase activity.