7α,12α-diacetoxy-3α-(p-tert-butoxycarbonylaminomethylphenyl)cholan-24-oic acid

Base Information

Chemical Name:7α,12α-diacetoxy-3α-(p-tert-butoxycarbonylaminomethylphenyl)cholan-24-oic acid
CAS No.:153204-96-7
Molecular Formula:C₄₀H₅₉NO₈
Molecular Weight:681.91
Hs Code.:

Synonyms:7α,12α-diacetoxy-3α-(p-tert-butoxycarbonylaminomethylphenyl)cholan-24-oic acid

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Chemical Property of 7α,12α-diacetoxy-3α-(p-tert-butoxycarbonylaminomethylphenyl)cholan-24-oic acid

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Technology Process of 7α,12α-diacetoxy-3α-(p-tert-butoxycarbonylaminomethylphenyl)cholan-24-oic acid

There total 6 articles about 7α,12α-diacetoxy-3α-(p-tert-butoxycarbonylaminomethylphenyl)cholan-24-oic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 125627-00-1
3α-(p-aminomethyl)phenyl-7α,12α-diacetoxycholan-24-oic acid

: 153204-96-7
7α,12α-diacetoxy-3α-(p-tert-butoxycarbonylaminomethylphenyl)cholan-24-oic acid

Guidance literature:: With lithium hydroxide; triethylamine; 1.) H₂O, r.t., 6 d, 2.) H₂O, r.t., 1 h;
DOI:10.1016/S0040-4020(01)80185-X

Reference yield:

: 69889-89-0
methyl 7,12-diacetoxycholate

: 153204-96-7
7α,12α-diacetoxy-3α-(p-tert-butoxycarbonylaminomethylphenyl)cholan-24-oic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 9.75 g / pyridinium chlorochromate / CH₂Cl₂ / 1.5 h

3: 95 percent / 1.08 M aqueous NaOH / tetrahydrofuran; methanol / 5 h / Ambient temperature

4: 95 percent / 1.) 1 M aqueous LiOH, 2.) TRIETHYLAMINE / 1.) H₂O, r.t., 6 d, 2.) H₂O, r.t., 1 h

With lithium hydroxide; sodium hydroxide; triethylamine; pyridinium chlorochromate; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0040-4020(01)80185-X

Reference yield:

: 4947-65-3
methyl 3-keto-7,12-diacetylcholate

: 153204-96-7
7α,12α-diacetoxy-3α-(p-tert-butoxycarbonylaminomethylphenyl)cholan-24-oic acid

Guidance literature:: Multi-step reaction with 3 steps

2: 95 percent / 1.08 M aqueous NaOH / tetrahydrofuran; methanol / 5 h / Ambient temperature

3: 95 percent / 1.) 1 M aqueous LiOH, 2.) TRIETHYLAMINE / 1.) H₂O, r.t., 6 d, 2.) H₂O, r.t., 1 h

With lithium hydroxide; sodium hydroxide; triethylamine; In tetrahydrofuran; methanol;
DOI:10.1016/S0040-4020(01)80185-X