3-[trans-4-(4-acetyl-piperazine-1-carbonyl)-cyclohexylmethyl]-5-((E)-3-methoxy-propenyl)-1-methyl-1,3-dihydro-imidazo[4,5-b]pyridin-2-one

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Chemical Name:3-[trans-4-(4-acetyl-piperazine-1-carbonyl)-cyclohexylmethyl]-5-((E)-3-methoxy-propenyl)-1-methyl-1,3-dihydro-imidazo[4,5-b]pyridin-2-one
CAS No.:1402006-35-2
Molecular Formula:C₂₅H₃₅N₅O₄
Molecular Weight:469.584
Hs Code.:

Synonyms:3-[trans-4-(4-acetyl-piperazine-1-carbonyl)-cyclohexylmethyl]-5-((E)-3-methoxy-propenyl)-1-methyl-1,3-dihydro-imidazo[4,5-b]pyridin-2-one

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Chemical Property of 3-[trans-4-(4-acetyl-piperazine-1-carbonyl)-cyclohexylmethyl]-5-((E)-3-methoxy-propenyl)-1-methyl-1,3-dihydro-imidazo[4,5-b]pyridin-2-one

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Technology Process of 3-[trans-4-(4-acetyl-piperazine-1-carbonyl)-cyclohexylmethyl]-5-((E)-3-methoxy-propenyl)-1-methyl-1,3-dihydro-imidazo[4,5-b]pyridin-2-one

There total 6 articles about 3-[trans-4-(4-acetyl-piperazine-1-carbonyl)-cyclohexylmethyl]-5-((E)-3-methoxy-propenyl)-1-methyl-1,3-dihydro-imidazo[4,5-b]pyridin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: ((E)-3-methoxy-propenyl)-(4,4,5,5-tetramethyl-[1,3]dioxolan-2-yl)-borane

: 1402006-34-1
3-[trans 4-(4-acetyl-piperazine-1-carbonyl)cyclohexylmethyl]-5-bromo-1-methyl-1,3-dihydro-imidazo[4,5-b]pyridin-2-one

: 1402006-35-2
3-[trans-4-(4-acetyl-piperazine-1-carbonyl)-cyclohexylmethyl]-5-((E)-3-methoxy-propenyl)-1-methyl-1,3-dihydro-imidazo[4,5-b]pyridin-2-one

Guidance literature:: With potassium phosphate; palladium diacetate; tricyclohexylphosphine; In water; toluene; at 90 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

: 55304-80-8
2,6-dibromo-3-nitropyridine

: 1402006-35-2
3-[trans-4-(4-acetyl-piperazine-1-carbonyl)-cyclohexylmethyl]-5-((E)-3-methoxy-propenyl)-1-methyl-1,3-dihydro-imidazo[4,5-b]pyridin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / toluene / 5 h / 60 °C

2.1: hydrogen / tetrahydrofuran; water / 6 h / 20 - 45 °C / 3750.38 Torr

2.2: 20 °C / 3750.38 Torr

3.1: triethylamine / tetrahydrofuran / 0 - 60 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h

4.2: 4 h / 20 °C

5.1: potassium phosphate; tricyclohexylphosphine; palladium diacetate / toluene; water / 0.17 h / 90 °C / Microwave irradiation

With potassium phosphate; hydrogen; palladium diacetate; potassium carbonate; triethylamine; tricyclohexylphosphine; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1402008-68-7
1-[trans 4-(4-aminomethyl-cyclohexanecarbonyl)-piperazin-1-yl]-ethanone

: 1402006-35-2
3-[trans-4-(4-acetyl-piperazine-1-carbonyl)-cyclohexylmethyl]-5-((E)-3-methoxy-propenyl)-1-methyl-1,3-dihydro-imidazo[4,5-b]pyridin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / toluene / 5 h / 60 °C

2.1: hydrogen / tetrahydrofuran; water / 6 h / 20 - 45 °C / 3750.38 Torr

2.2: 20 °C / 3750.38 Torr

3.1: triethylamine / tetrahydrofuran / 0 - 60 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h

4.2: 4 h / 20 °C

5.1: potassium phosphate; tricyclohexylphosphine; palladium diacetate / toluene; water / 0.17 h / 90 °C / Microwave irradiation

With potassium phosphate; hydrogen; palladium diacetate; potassium carbonate; triethylamine; tricyclohexylphosphine; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene;