3-Borono-5-methoxybenzoic acid

Base Information

• Chemical Name: 3-Borono-5-methoxybenzoic acid
• CAS No.: 1050424-08-2
• Molecular Formula: C₈H₉BO₅
• Molecular Weight: 195.967
• Hs Code.: 2931900090
• Mol file: 1050424-08-2.mol

Synonyms:3-carboxy-5-methoxyphenylboronic acid

Chemical Property of 3-Borono-5-methoxybenzoic acid

Chemical Property:

• Boiling Point: 471.4±55.0 °C(Predicted)
• PKA: 4.09±0.10(Predicted)
• Density: 1.39±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

3-Carboxy-5-methoxyphenylboronicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Borono-5-methoxybenzoic acid

There total 1 articles about 3-Borono-5-methoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

carbon dioxide (124-38-9,18923-20-1) + 3,5-dibromoanisole (74137-36-3) → (3-bromo-5-methoxyphenyl)boronic acid (849062-12-0) + 3-carboxy-5-methoxyphenylboronic acid (1050424-08-2)

Guidance literature:

3,5-dibromoanisole; With n-butyllithium; In diethyl ether; hexane; at -80 ℃; for 0.5h; Inert atmosphere;

With Triisopropyl borate; In tetrahydrofuran; diethyl ether; hexane; at -70 ℃; for 0.5h; Inert atmosphere;

carbon dioxide; Further stages;

DOI:10.1002/ejoc.200800245

Reference yield:

3-carboxy-5-methoxyphenylboronic acid (1050424-08-2) + (R)-N-((2-((N-(benzyloxy)formamido)methyl)heptanamido)methyl)-5-bromofuran-2-carboxamide → (R)-3-(5-(((2-((N-(benzyloxy)formamido)methyl)heptanamido)methyl)carbamoyl)furan-2-yl)-5-methoxybenzoic acid + (R)-3-(5-(((2-(((benzyloxy)amino)methyl)heptanamido)methyl)carbamoyl)furan-2-yl)-5-methoxybenzoic acid

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In 1,4-dioxane; at 100 ℃; for 0.0833333h; Overall yield = 531 mg; Microwave irradiation;

Reference yield:

3-carboxy-5-methoxyphenylboronic acid (1050424-08-2) + (R)-N-((2-((N-(benzyloxy)formamido)methyl)heptanamido)methyl)-5-bromofuran-2-carboxamide → (R)-3-(5-(((2-((N-(benzyloxy)formamido)methyl)heptanamido)methyl)carbamoyl)furan-2-yl)-5-methoxybenzoic acid

Guidance literature:

3-carboxy-5-methoxyphenylboronic acid; (R)-N-((2-((N-(benzyloxy)formamido)methyl)heptanamido)methyl)-5-bromofuran-2-carboxamide; With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In 1,4-dioxane; at 100 ℃; for 0.0833333h; Microwave irradiation;

With 5-methyl-2-thioxo-1,3,4-thiadiazole-3(2H)-carbaldehyde; In dichloromethane; at 20 ℃; for 0.75h;

upstream raw materials:

carbon dioxide

3,5-dibromoanisole

Refernces