ethyl 6-[(4-chlorophenyl)methyl]-7-hydroxy-5-methylpyrazolo[1,5-a]pyrimidine-3-carboxylate

Base Information

Chemical Name:ethyl 6-[(4-chlorophenyl)methyl]-7-hydroxy-5-methylpyrazolo[1,5-a]pyrimidine-3-carboxylate
CAS No.:1310199-31-5
Molecular Formula:C₁₇H₁₆ClN₃O₃
Molecular Weight:345.785
Hs Code.:

Synonyms:ethyl 6-[(4-chlorophenyl)methyl]-7-hydroxy-5-methylpyrazolo[1,5-a]pyrimidine-3-carboxylate

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Chemical Property of ethyl 6-[(4-chlorophenyl)methyl]-7-hydroxy-5-methylpyrazolo[1,5-a]pyrimidine-3-carboxylate

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Technology Process of ethyl 6-[(4-chlorophenyl)methyl]-7-hydroxy-5-methylpyrazolo[1,5-a]pyrimidine-3-carboxylate

There total 1 articles about ethyl 6-[(4-chlorophenyl)methyl]-7-hydroxy-5-methylpyrazolo[1,5-a]pyrimidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 622-95-7
4-chlorobenzyl bromide

: 1310199-31-5
ethyl 6-[(4-chlorophenyl)methyl]-7-hydroxy-5-methylpyrazolo[1,5-a]pyrimidine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium carbonate / N,N-dimethyl-formamide / 48 h / 80 °C

2: phosphoric acid / ethanol; water / 48 h / Reflux

With phosphoric acid; lithium carbonate; In ethanol; water; N,N-dimethyl-formamide;

Reference yield: 89.0%

: 1310199-31-5
ethyl 6-[(4-chlorophenyl)methyl]-7-hydroxy-5-methylpyrazolo[1,5-a]pyrimidine-3-carboxylate

: 702670-02-8
6-[(4-chlorophenyl)methyl]-7-hydroxy-5-methylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid

Guidance literature:: ethyl 6-[(4-chlorophenyl)methyl]-7-hydroxy-5-methylpyrazolo[1,5-a]pyrimidine-3-carboxylate; With water; potassium hydroxide; In ethanol; for 48h; Reflux;

With phosphoric acid; In ethanol; water; for 1h; pH=3; Reflux;

Reference yield:

: 1310199-31-5
ethyl 6-[(4-chlorophenyl)methyl]-7-hydroxy-5-methylpyrazolo[1,5-a]pyrimidine-3-carboxylate

: 1370227-04-5
6-[(4-chlorophenyl)methyl]-7-hydroxy-N,N,5-trimethylpyrazolo[1,5-a]pyrimidine-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide; water / ethanol / 48 h / Reflux

1.2: 1 h / pH 3 / Reflux

2.1: thionyl chloride / 2 h / Reflux

2.2: 18 h / 0 - 20 °C

With thionyl chloride; water; potassium hydroxide; In ethanol;