5-(4-(2-(tetrahydropyran-2-yloxy)ethoxy)phenyl)-3H-1,2-dithiole-3-thione

Base Information

• Chemical Name: 5-(4-(2-(tetrahydropyran-2-yloxy)ethoxy)phenyl)-3H-1,2-dithiole-3-thione
• CAS No.: 1314004-82-4
• Molecular Formula: C₁₆H₁₈O₃S₃
• Molecular Weight: 354.515
• Mol file: 1314004-82-4.mol

Synonyms:5-(4-(2-(tetrahydropyran-2-yloxy)ethoxy)phenyl)-3H-1,2-dithiole-3-thione

Chemical Property of 5-(4-(2-(tetrahydropyran-2-yloxy)ethoxy)phenyl)-3H-1,2-dithiole-3-thione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(4-(2-(tetrahydropyran-2-yloxy)ethoxy)phenyl)-3H-1,2-dithiole-3-thione

There total 1 articles about 5-(4-(2-(tetrahydropyran-2-yloxy)ethoxy)phenyl)-3H-1,2-dithiole-3-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-(tetrahydropyran-2-yloxy)ethanol (2162-31-4) + desmethyl anethole trithione (18274-81-2) → 5-(4-(2-(tetrahydropyran-2-yloxy)ethoxy)phenyl)-3H-1,2-dithiole-3-thione (1314004-82-4)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at -15 - 20 ℃; for 24h;

DOI:10.1021/jm2004514

Reference yield: 40.0%

5-(4-(2-(tetrahydropyran-2-yloxy)ethoxy)phenyl)-3H-1,2-dithiole-3-thione (1314004-82-4) → 5-(4-(2-hydroxyethoxy)phenyl)-3H-1,2-dithiole-3-thione (1314004-83-5)

Guidance literature:

With methanol; pyridinium p-toluenesulfonate; at 55 ℃; for 2h;

DOI:10.1021/jm2004514

Reference yield:

5-(4-(2-(tetrahydropyran-2-yloxy)ethoxy)phenyl)-3H-1,2-dithiole-3-thione (1314004-82-4) → ((2-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)ethoxy)carbonyloxy)methyl 2-(acetyloxy)benzoate (1314004-81-3)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol; pyridinium p-toluenesulfonate / 2 h / 55 °C

2: 4-methyl-morpholine / dichloromethane / 25 h / -15 - 20 °C

With 4-methyl-morpholine; methanol; pyridinium p-toluenesulfonate; In dichloromethane;

DOI:10.1021/jm2004514

upstream raw materials:

2-(tetrahydropyran-2-yloxy)ethanol

desmethyl anethole trithione

Downstream raw materials:

5-(4-(2-hydroxyethoxy)phenyl)-3H-1,2-dithiole-3-thione

((2-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)ethoxy)carbonyloxy)methyl 2-(acetyloxy)benzoate