5-bromo-1-(4-methoxy-benzenesulfonyl)-2,3-dihydro-1H-indol-7-ylamine

Base Information

• Chemical Name: 5-bromo-1-(4-methoxy-benzenesulfonyl)-2,3-dihydro-1H-indol-7-ylamine
• CAS No.: 916484-30-5
• Molecular Formula: C₁₅H₁₅BrN₂O₃S
• Molecular Weight: 383.266
• Mol file: 916484-30-5.mol

Synonyms:5-bromo-1-(4-methoxy-benzenesulfonyl)-2,3-dihydro-1H-indol-7-ylamine

Chemical Property of 5-bromo-1-(4-methoxy-benzenesulfonyl)-2,3-dihydro-1H-indol-7-ylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-bromo-1-(4-methoxy-benzenesulfonyl)-2,3-dihydro-1H-indol-7-ylamine

There total 3 articles about 5-bromo-1-(4-methoxy-benzenesulfonyl)-2,3-dihydro-1H-indol-7-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

5-bromo-1-(4-methoxy-benzenesulfonyl)-7-nitro-2,3-dihydro-1H-indole → 5-bromo-1-(4-methoxy-benzenesulfonyl)-2,3-dihydro-1H-indol-7-ylamine (916484-30-5)

Guidance literature:

With iron; ammonium chloride; In water; isopropyl alcohol; for 8h; Reflux;

DOI:10.1016/j.bmc.2014.06.042

Reference yield:

5-Bromo-7-nitroindoline (80166-90-1) → 5-bromo-1-(4-methoxy-benzenesulfonyl)-2,3-dihydro-1H-indol-7-ylamine (916484-30-5)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 10 h / 95 - 100 °C / Inert atmosphere

2: iron; ammonium chloride / water; isopropyl alcohol / 8 h / Reflux

With pyridine; iron; ammonium chloride; In water; isopropyl alcohol;

DOI:10.1016/j.bmc.2014.06.042

Reference yield:

4-methoxy-phenyl-sulphonyl chloride (98-68-0) → 5-bromo-1-(4-methoxy-benzenesulfonyl)-2,3-dihydro-1H-indol-7-ylamine (916484-30-5)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 10 h / 95 - 100 °C / Inert atmosphere

2: iron; ammonium chloride / water; isopropyl alcohol / 8 h / Reflux

With pyridine; iron; ammonium chloride; In water; isopropyl alcohol;

DOI:10.1016/j.bmc.2014.06.042

upstream raw materials:

5-Bromo-7-nitroindoline

4-methoxy-phenyl-sulphonyl chloride

Downstream raw materials:

1-(4-methoxy-benzenesulfonyl)-2,3-dihydro-1H-indol-7-ylamine