3-ethynyl-4-fluorophthalonitrile

Base Information

Chemical Name:3-ethynyl-4-fluorophthalonitrile
CAS No.:1539314-98-1
Molecular Formula:C₁₀H₃FN₂
Molecular Weight:170.146
Hs Code.:

Synonyms:3-ethynyl-4-fluorophthalonitrile

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Chemical Property of 3-ethynyl-4-fluorophthalonitrile

Chemical Property:

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Technology Process of 3-ethynyl-4-fluorophthalonitrile

There total 4 articles about 3-ethynyl-4-fluorophthalonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1539314-94-7
4-fluoro-3-((trimethylsilyl)ethynyl)phthalonitrile

: 1539314-98-1
3-ethynyl-4-fluorophthalonitrile

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.0833333h; Inert atmosphere;

Reference yield:

: 2369-37-1
1,2,-dibromo-4-fluorobenzene

: 1539314-98-1
3-ethynyl-4-fluorophthalonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C

1.2: 0.5 h

2.1: diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 0.17 h / Sealed tube; Sonication

2.2: 40 h / 40 °C

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl acetamide / 26.16 h / 100 °C / Sealed tube; Sonication

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.08 h / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; tetrabutyl ammonium fluoride; diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl acetamide;

Reference yield:

: 1539314-91-4
1,2-dibromo-4-fluoro-3-iodobenzene

: 1539314-98-1
3-ethynyl-4-fluorophthalonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 0.17 h / Sealed tube; Sonication

1.2: 40 h / 40 °C

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl acetamide / 26.16 h / 100 °C / Sealed tube; Sonication

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.08 h / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; tetrabutyl ammonium fluoride; diisopropylamine; In tetrahydrofuran; N,N-dimethyl acetamide;